| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248594 |
| PPP2CA | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248637 |
| PRKCD | PRKCD | Thr507 | FGESRAStFCGTPDY | phosphorylation up-regulates | 19366211 | SIGNOR-185287 |
| PDPK1 | PRKCD | Thr507 | FGESRAStFCGTPDY | phosphorylation up-regulates activity | 9748166 | SIGNOR-250269 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248594 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248637 |
| PRKCD | phosphorylation up-regulates → | PRKCD PThr507 | phosphorylation up-regulates → | PRKCD | 19366211 | SIGNOR-185287 |
| PDPK1 | phosphorylation up-regulates → | PRKCD PThr507 | phosphorylation up-regulates → | PRKCD | 9748166 | SIGNOR-250269 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248594 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248637 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-185287 |
| PDPK1 | phosphorylation → up-regulates activity | PRKCD | SIGNOR-250269 |
