| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | CALD1 | Ser759 | KTPDGNKsPAPKPSD | phosphorylation down-regulates | 10514499 | SIGNOR-71041 |
| ERK1/2 | CALD1 | – | phosphorylation down-regulates | 10514499 | SIGNOR-270162 | |
| MAPK1 | CALD1 | Ser759 | KTPDGNKsPAPKPSD | phosphorylation down-regulates | 10514499 | SIGNOR-71033 |
| PAK3 | CALD1 | Ser744 | GLKVGVSsRINEWLT | phosphorylation down-regulates | 20858431 | SIGNOR-167980 |
| MAPK3 | CALD1 | Ser789 | QSVDKVTsPTKV | phosphorylation down-regulates | 10514499 | SIGNOR-71045 |
| PAK3 | CALD1 | Ser714 | EGVRNIKsMWEKGNV | phosphorylation down-regulates | 20858431 | SIGNOR-167976 |
| Gbeta | CALD1 | – | phosphorylation down-regulates | 10514499 | SIGNOR-270049 | |
| CDK5 | CALD1 | Ser789 | QSVDKVTsPTKV | phosphorylation down-regulates quantity by destabilization | 21791703 | SIGNOR-280215 |
| PRKCA | CALD1 | Ser677 | AIVSKIDsRLEQYTS | phosphorylation down-regulates | 8182108 | SIGNOR-36796 |
| CAMK2A | CALD1 | Ser656 | RAEFLNKsVQKSSGV | phosphorylation down-regulates | 2170388 | SIGNOR-22635 |
| PRKCA | CALD1 | Ser643 | CFTPKGSsLKIEERA | phosphorylation down-regulates | 8182108 | SIGNOR-36788 |
| PRKCA | CALD1 | Ser656 | RAEFLNKsVQKSSGV | phosphorylation down-regulates | 8182108 | SIGNOR-36792 |
| CAMK2A | CALD1 | Ser643 | CFTPKGSsLKIEERA | phosphorylation down-regulates | 2170388 | SIGNOR-22631 |
| MAPK1 | CALD1 | Ser789 | QSVDKVTsPTKV | phosphorylation down-regulates | 10514499 | SIGNOR-71037 |
| MAPK3 | CALD1 | Ser759 | KTPDGNKsPAPKPSD | phosphorylation down-regulates | 11983427 | SIGNOR-86741 |
| MYLK | CALD1 | Ser744 | GLKVGVSsRINEWLT | phosphorylation down-regulates | 20536391 | SIGNOR-166049 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | CALD1 PSer759 | phosphorylation down-regulates ⊣ | CALD1 | 10514499 | SIGNOR-71041 |
| MAPK1 | phosphorylation up-regulates → | CALD1 PSer759 | phosphorylation down-regulates ⊣ | CALD1 | 10514499 | SIGNOR-71033 |
| PAK3 | phosphorylation up-regulates → | CALD1 PSer744 | phosphorylation down-regulates ⊣ | CALD1 | 20858431 | SIGNOR-167980 |
| MAPK3 | phosphorylation up-regulates → | CALD1 PSer789 | phosphorylation down-regulates ⊣ | CALD1 | 10514499 | SIGNOR-71045 |
| PAK3 | phosphorylation up-regulates → | CALD1 PSer714 | phosphorylation down-regulates ⊣ | CALD1 | 20858431 | SIGNOR-167976 |
| CDK5 | phosphorylation up-regulates → | CALD1 PSer789 | phosphorylation down-regulates ⊣ | CALD1 | 21791703 | SIGNOR-280215 |
| PRKCA | phosphorylation up-regulates → | CALD1 PSer677 | phosphorylation down-regulates ⊣ | CALD1 | 8182108 | SIGNOR-36796 |
| CAMK2A | phosphorylation up-regulates → | CALD1 PSer656 | phosphorylation down-regulates ⊣ | CALD1 | 2170388 | SIGNOR-22635 |
| PRKCA | phosphorylation up-regulates → | CALD1 PSer643 | phosphorylation down-regulates ⊣ | CALD1 | 8182108 | SIGNOR-36788 |
| PRKCA | phosphorylation up-regulates → | CALD1 PSer656 | phosphorylation down-regulates ⊣ | CALD1 | 8182108 | SIGNOR-36792 |
| CAMK2A | phosphorylation up-regulates → | CALD1 PSer643 | phosphorylation down-regulates ⊣ | CALD1 | 2170388 | SIGNOR-22631 |
| MAPK1 | phosphorylation up-regulates → | CALD1 PSer789 | phosphorylation down-regulates ⊣ | CALD1 | 10514499 | SIGNOR-71037 |
| MAPK3 | phosphorylation up-regulates → | CALD1 PSer759 | phosphorylation down-regulates ⊣ | CALD1 | 11983427 | SIGNOR-86741 |
| MYLK | phosphorylation up-regulates → | CALD1 PSer744 | phosphorylation down-regulates ⊣ | CALD1 | 20536391 | SIGNOR-166049 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | CALD1 | SIGNOR-71041 |
| ERK1/2 | phosphorylation down-regulates | CALD1 | SIGNOR-270162 |
| MAPK1 | phosphorylation down-regulates | CALD1 | SIGNOR-71033 |
| PAK3 | phosphorylation down-regulates | CALD1 | SIGNOR-167980 |
| MAPK3 | phosphorylation down-regulates | CALD1 | SIGNOR-71045 |
| PAK3 | phosphorylation down-regulates | CALD1 | SIGNOR-167976 |
| Gbeta | phosphorylation down-regulates | CALD1 | SIGNOR-270049 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | CALD1 | SIGNOR-280215 |
| PRKCA | phosphorylation down-regulates | CALD1 | SIGNOR-36796 |
| CAMK2A | phosphorylation down-regulates | CALD1 | SIGNOR-22635 |
| PRKCA | phosphorylation down-regulates | CALD1 | SIGNOR-36788 |
| PRKCA | phosphorylation down-regulates | CALD1 | SIGNOR-36792 |
| CAMK2A | phosphorylation down-regulates | CALD1 | SIGNOR-22631 |
| MAPK1 | phosphorylation down-regulates | CALD1 | SIGNOR-71037 |
| MAPK3 | phosphorylation down-regulates | CALD1 | SIGNOR-86741 |
| MYLK | phosphorylation down-regulates | CALD1 | SIGNOR-166049 |
