Summary

Name CALD1
Full Name Caldesmon
Synonyms CDM | CAD, CDM
Primary ID Q05682
Links - -
Type protein
Relations 13
Function Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Smooth Muscle, Muscle, Smooth Muscle