| Name | PTPN11 |
| ID | Q06124 |
| Role | phosphatase |
| Enzymatic Domains |
SH2 1 6-102 PROSITE-ProRule
SH2 2 112-216 PROSITE-ProRule
Tyrosine-protein phosphatase 247-517 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | SPRY1 | – | dephosphorylation down-regulates | 16481357 | SIGNOR-144547 | |
| PTPN11 | JAK2 | Tyr570 | VRREVGDyGQLHETE | dephosphorylation up-regulates activity | 30108215 | SIGNOR-277037 |
| PTPN11 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation up-regulates quantity by stabilization | 14522994 | SIGNOR-248665 |
| PTPN11 | MPZL1 | Tyr263 | NKSESVVyADIRKN | dephosphorylation down-regulates | 10681522 | SIGNOR-75220 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 12582165 | SIGNOR-236424 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 14560030 | SIGNOR-248666 |
| PTPN11 | NRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-255754 |
| PTPN11 | HRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-252094 |
| PTPN11 | KRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-255982 |
| PTPN11 | ERBB2 | Tyr1023 | DLVDAEEyLVPQQGF | dephosphorylation down-regulates | 32024694 | SIGNOR-262957 |
| PTPN11 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248667 |
| PTPN11 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248668 |
| PTPN11 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248669 |
| PTPN11 | SLC25A4 | – | dephosphorylation down-regulates activity | 29255148 | SIGNOR-277124 | |
| PTPN11 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 18482983 | SIGNOR-248670 |
| PTPN11 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248671 |
| PTPN11 | FGFR2 | – | dephosphorylation down-regulates activity | 23420874 | SIGNOR-277030 | |
| PTPN11 | HOXA10 | – | dephosphorylation up-regulates | 19022774 | SIGNOR-182475 | |
| PTPN11 | CSF2RB | – | dephosphorylation up-regulates | 9162089 | SIGNOR-48557 | |
| PTPN11 | CTNNA1 | Tyr148 | LADMADVyKLLVQLK | dephosphorylation down-regulates | 16767162 | SIGNOR-147075 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 10660596 | SIGNOR-74856 |
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 10660596 | SIGNOR-74860 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 7515062 | SIGNOR-27024 |
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 7515062 | SIGNOR-27028 |
| PTPN11 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 16611743 | SIGNOR-272404 |
| PTPN11 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248673 |
| PTPN11 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248672 |
| PTPN11 | SYK | – | dephosphorylation down-regulates activity | 23182168 | SIGNOR-277085 | |
| PTPN11 | CDKN1B | – | dephosphorylation up-regulates activity | 19066472 | SIGNOR-277168 | |
| PTPN11 | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | dephosphorylation up-regulates activity | 23420874 | SIGNOR-276995 |
| PTPN11 | IRF8 | – | dephosphorylation down-regulates activity | 27769062 | SIGNOR-277173 | |
| PTPN11 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates | 16920701 | SIGNOR-148926 |
| PTPN11 | ITK | – | dephosphorylation down-regulates activity | 33624224 | SIGNOR-277174 | |
| PTPN11 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 32140036 | SIGNOR-276950 |
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates | 10068651 | SIGNOR-236262 |
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates | 10068651 | SIGNOR-236254 |
| PTPN11 | GAB1 | Tyr589 | SHDSEENyVPMNPNL | dephosphorylation down-regulates activity | 10068651 | SIGNOR-236258 |
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248674 |
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248675 |
| PTPN11 | PTK2B | Tyr906 | CQLPPEGyVVVVKNV | dephosphorylation down-regulates activity | 10880513 | SIGNOR-277084 |
| PTPN11 | GRB7 | – | dephosphorylation up-regulates activity | 20142421 | SIGNOR-277169 | |
| PTPN11 | NEDD9 | – | dephosphorylation down-regulates activity | 19275884 | SIGNOR-277083 | |
| PTPN11 | PDCD1 | – | dephosphorylation down-regulates activity | 32437509 | SIGNOR-277052 | |
| PTPN11 | NTRK2 | – | dephosphorylation down-regulates activity | 28947394 | SIGNOR-277123 | |
| PTPN11 | CDC73 | – | dephosphorylation up-regulates activity | 21726809 | SIGNOR-277036 | |
| PTPN11 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | dephosphorylation up-regulates | 19287004 | SIGNOR-184604 |
| PTPN11 | MAP3K5 | – | dephosphorylation up-regulates quantity by stabilization | 19287004 | SIGNOR-276144 | |
| PTPN11 | GAB2 | Tyr614 | KSTGSVDyLALDFQP | dephosphorylation down-regulates | 15170389 | SIGNOR-124958 |
| PTPN11 | α-Catenin | – | dephosphorylation down-regulates activity | 16767162 | SIGNOR-265824 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | JAK2 PTyr570 | dephosphorylation down-regulates ⊣ | JAK2 | 30108215 | SIGNOR-277037 |
| PTPN11 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation down-regulates ⊣ | JAK2 | 14522994 | SIGNOR-248665 |
| PTPN11 | dephosphorylation down-regulates ⊣ | MPZL1 PTyr263 | dephosphorylation up-regulates → | MPZL1 | 10681522 | SIGNOR-75220 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 12582165 | SIGNOR-236424 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 14560030 | SIGNOR-248666 |
| PTPN11 | dephosphorylation down-regulates ⊣ | NRAS PTyr32 | dephosphorylation down-regulates ⊣ | NRAS | 26617336 | SIGNOR-255754 |
| PTPN11 | dephosphorylation down-regulates ⊣ | HRAS PTyr32 | dephosphorylation down-regulates ⊣ | HRAS | 26617336 | SIGNOR-252094 |
| PTPN11 | dephosphorylation down-regulates ⊣ | KRAS PTyr32 | dephosphorylation down-regulates ⊣ | KRAS | 26617336 | SIGNOR-255982 |
| PTPN11 | dephosphorylation down-regulates ⊣ | ERBB2 PTyr1023 | dephosphorylation up-regulates → | ERBB2 | 32024694 | SIGNOR-262957 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248667 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248668 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248669 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 18482983 | SIGNOR-248670 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248671 |
| PTPN11 | dephosphorylation down-regulates ⊣ | CTNNA1 PTyr148 | dephosphorylation up-regulates → | CTNNA1 | 16767162 | SIGNOR-147075 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74856 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74860 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27024 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27028 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 16611743 | SIGNOR-272404 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PSer727 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248673 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248672 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GRB2 PTyr209 | dephosphorylation down-regulates ⊣ | GRB2 | 23420874 | SIGNOR-276995 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 16920701 | SIGNOR-148926 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 32140036 | SIGNOR-276950 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236262 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236254 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr589 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236258 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248674 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248675 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2B PTyr906 | dephosphorylation up-regulates → | PTK2B | 10880513 | SIGNOR-277084 |
| PTPN11 | dephosphorylation down-regulates ⊣ | MAP3K5 PTyr718 | dephosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-184604 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB2 PTyr614 | dephosphorylation up-regulates → | GAB2 | 15170389 | SIGNOR-124958 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates | SPRY1 | SIGNOR-144547 |
| PTPN11 | dephosphorylation → up-regulates activity | JAK2 | SIGNOR-277037 |
| PTPN11 | dephosphorylation → up-regulates quantity by stabilization | JAK2 | SIGNOR-248665 |
| PTPN11 | dephosphorylation down-regulates | MPZL1 | SIGNOR-75220 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-236424 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248666 |
| PTPN11 | dephosphorylation → up-regulates activity | NRAS | SIGNOR-255754 |
| PTPN11 | dephosphorylation → up-regulates activity | HRAS | SIGNOR-252094 |
| PTPN11 | dephosphorylation → up-regulates activity | KRAS | SIGNOR-255982 |
| PTPN11 | dephosphorylation down-regulates | ERBB2 | SIGNOR-262957 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248667 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248668 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248669 |
| PTPN11 | dephosphorylation → down-regulates activity | SLC25A4 | SIGNOR-277124 |
| PTPN11 | dephosphorylation → down-regulates activity | SRC | SIGNOR-248670 |
| PTPN11 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248671 |
| PTPN11 | dephosphorylation → down-regulates activity | FGFR2 | SIGNOR-277030 |
| PTPN11 | dephosphorylation → up-regulates | HOXA10 | SIGNOR-182475 |
| PTPN11 | dephosphorylation → up-regulates | CSF2RB | SIGNOR-48557 |
| PTPN11 | dephosphorylation down-regulates | CTNNA1 | SIGNOR-147075 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74856 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74860 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27024 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27028 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-272404 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248673 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248672 |
| PTPN11 | dephosphorylation → down-regulates activity | SYK | SIGNOR-277085 |
| PTPN11 | dephosphorylation → up-regulates activity | CDKN1B | SIGNOR-277168 |
| PTPN11 | dephosphorylation → up-regulates activity | GRB2 | SIGNOR-276995 |
| PTPN11 | dephosphorylation → down-regulates activity | IRF8 | SIGNOR-277173 |
| PTPN11 | dephosphorylation down-regulates | PTK2 | SIGNOR-148926 |
| PTPN11 | dephosphorylation → down-regulates activity | ITK | SIGNOR-277174 |
| PTPN11 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-276950 |
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236262 |
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236254 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-236258 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248674 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248675 |
| PTPN11 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-277084 |
| PTPN11 | dephosphorylation → up-regulates activity | GRB7 | SIGNOR-277169 |
| PTPN11 | dephosphorylation → down-regulates activity | NEDD9 | SIGNOR-277083 |
| PTPN11 | dephosphorylation → down-regulates activity | PDCD1 | SIGNOR-277052 |
| PTPN11 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-277123 |
| PTPN11 | dephosphorylation → up-regulates activity | CDC73 | SIGNOR-277036 |
| PTPN11 | dephosphorylation → up-regulates | MAP3K5 | SIGNOR-184604 |
| PTPN11 | dephosphorylation → up-regulates quantity by stabilization | MAP3K5 | SIGNOR-276144 |
| PTPN11 | dephosphorylation down-regulates | GAB2 | SIGNOR-124958 |
| PTPN11 | dephosphorylation → down-regulates activity | α-Catenin | SIGNOR-265824 |