Summary

Name PTPN11
Full Name Tyrosine-protein phosphatase non-receptor type 11
Synonyms Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3 | PTP2C, SHPTP2
Primary ID Q06124
Links - -
Type protein
Relations 43
Pathways EGFR, Acute Myeloid Leukemia, Noonan syndrome, FLT3 in AML
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PTPN11 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.36
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation JAK2 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.37
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:EGFR, Noonan syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.28
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation CTNNA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MPZL1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.34
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.37
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png dephosphorylation KRAS 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, Noonan syndrome
+ up-regulates activity img/direct-activation.png dephosphorylation NRAS 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ up-regulates activity img/direct-activation.png dephosphorylation HRAS 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.22
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.52
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation GAB1 0.57
Publications: 3 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation GAB2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation GAB1 0.57
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome
+ up-regulates img/direct-activation.png dephosphorylation MAP3K5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.36
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTPN11 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN11 0.62
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ down-regulates img/direct_inhibition.png dephosphorylation SPRY1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ up-regulates img/direct-activation.png dephosphorylation CSF2RB 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation HOXA10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.36
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia