| Name | PTPN11 |
| ID | Q06124 |
| Role | substrate |
| Enzymatic Domains |
SH2 1 6-102 PROSITE-ProRule
SH2 2 112-216 PROSITE-ProRule
Tyrosine-protein phosphatase 247-517 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | PTPN11 | Tyr580 | REDSARVyENVGLMQ | phosphorylation up-regulates activity | 18827006 | SIGNOR-278217 |
| PDGFRB | PTPN11 | Tyr542 | SKRKGHEyTNIKYSL | phosphorylation up-regulates activity | 8041791 | SIGNOR-250260 |
| PRKACA | PTPN11 | Ser189 | GGGERFDsLTDLVEH | phosphorylation down-regulates activity | 25802336 | SIGNOR-276892 |
| JAK1 | PTPN11 | Tyr327 | NSKPKKSyIATQGCL | phosphorylation up-regulates activity | 8995399 | SIGNOR-236274 |
| JAK1 | PTPN11 | Tyr304 | PNEPVSDyINANIIM | phosphorylation up-regulates activity | 8995399 | SIGNOR-236282 |
| PRKCA | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249138 |
| FRS2 | PTPN11 | – | phosphorylation up-regulates | 9632781 | SIGNOR-58196 | |
| PKA | PTPN11 | Ser189 | GGGERFDsLTDLVEH | phosphorylation down-regulates activity | 25802336 | SIGNOR-276894 |
| PRKCB | PTPN11 | Ser576 | CAEMREDsARVYENV | phosphorylation unknown | 11781100 | SIGNOR-249136 |
| PKA | PTPN11 | Thr73 | YGGEKFAtLAELVQY | phosphorylation down-regulates activity | 25802336 | SIGNOR-276893 |
| JAK2 | PTPN11 | Tyr327 | NSKPKKSyIATQGCL | phosphorylation up-regulates activity | 8995399 | SIGNOR-236270 |
| PRKCH | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249140 |
| PRKCH | PTPN11 | Ser576 | CAEMREDsARVYENV | phosphorylation unknown | 11781100 | SIGNOR-249137 |
| PRKCB | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249139 |
| PRKACA | PTPN11 | Thr73 | YGGEKFAtLAELVQY | phosphorylation down-regulates activity | 25802336 | SIGNOR-276891 |
| JAK2 | PTPN11 | Tyr304 | PNEPVSDyINANIIM | phosphorylation up-regulates activity | 8995399 | SIGNOR-236266 |
| EGFR | PTPN11 | Tyr542 | SKRKGHEyTNIKYSL | phosphorylation up-regulates activity | 19427850 | SIGNOR-279460 |
| KIT | PTPN11 | – | phosphorylation up-regulates activity | 22806893 | SIGNOR-256140 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | PTPN11 PTyr580 | phosphorylation up-regulates → | PTPN11 | 18827006 | SIGNOR-278217 |
| PDGFRB | phosphorylation up-regulates → | PTPN11 PTyr542 | phosphorylation up-regulates → | PTPN11 | 8041791 | SIGNOR-250260 |
| PRKACA | phosphorylation up-regulates → | PTPN11 PSer189 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276892 |
| JAK1 | phosphorylation up-regulates → | PTPN11 PTyr327 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236274 |
| JAK1 | phosphorylation up-regulates → | PTPN11 PTyr304 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236282 |
| PRKCA | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249138 |
| PKA | phosphorylation up-regulates → | PTPN11 PSer189 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276894 |
| PRKCB | phosphorylation up-regulates → | PTPN11 PSer576 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249136 |
| PKA | phosphorylation up-regulates → | PTPN11 PThr73 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276893 |
| JAK2 | phosphorylation up-regulates → | PTPN11 PTyr327 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236270 |
| PRKCH | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249140 |
| PRKCH | phosphorylation up-regulates → | PTPN11 PSer576 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249137 |
| PRKCB | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249139 |
| PRKACA | phosphorylation up-regulates → | PTPN11 PThr73 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276891 |
| JAK2 | phosphorylation up-regulates → | PTPN11 PTyr304 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236266 |
| EGFR | phosphorylation up-regulates → | PTPN11 PTyr542 | phosphorylation up-regulates → | PTPN11 | 19427850 | SIGNOR-279460 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-278217 |
| PDGFRB | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-250260 |
| PRKACA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276892 |
| JAK1 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236274 |
| JAK1 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236282 |
| PRKCA | phosphorylation → unknown | PTPN11 | SIGNOR-249138 |
| FRS2 | phosphorylation → up-regulates | PTPN11 | SIGNOR-58196 |
| PKA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276894 |
| PRKCB | phosphorylation → unknown | PTPN11 | SIGNOR-249136 |
| PKA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276893 |
| JAK2 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236270 |
| PRKCH | phosphorylation → unknown | PTPN11 | SIGNOR-249140 |
| PRKCH | phosphorylation → unknown | PTPN11 | SIGNOR-249137 |
| PRKCB | phosphorylation → unknown | PTPN11 | SIGNOR-249139 |
| PRKACA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276891 |
| JAK2 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236266 |
| EGFR | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-279460 |
| KIT | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-256140 |