| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | PTPN11 | Thr73 | YGGEKFAtLAELVQY | phosphorylation down-regulates activity | 25802336 | SIGNOR-276893 |
| PRKACA | PTPN11 | Thr73 | YGGEKFAtLAELVQY | phosphorylation down-regulates activity | 25802336 | SIGNOR-276891 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | PTPN11 PThr73 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276893 |
| PRKACA | phosphorylation up-regulates → | PTPN11 PThr73 | phosphorylation down-regulates ⊣ | PTPN11 | 25802336 | SIGNOR-276891 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276893 |
| PRKACA | phosphorylation → down-regulates activity | PTPN11 | SIGNOR-276891 |