| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249139 |
| PRKCH | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249140 |
| PRKCA | PTPN11 | Ser595 | GLMQQQKsFR | phosphorylation unknown | 11781100 | SIGNOR-249138 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249139 |
| PRKCH | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249140 |
| PRKCA | phosphorylation up-regulates → | PTPN11 PSer595 | phosphorylation down-regulates ⊣ | PTPN11 | 11781100 | SIGNOR-249138 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation → unknown | PTPN11 | SIGNOR-249139 |
| PRKCH | phosphorylation → unknown | PTPN11 | SIGNOR-249140 |
| PRKCA | phosphorylation → unknown | PTPN11 | SIGNOR-249138 |
