Entity Details

Name PTPN11_Tyr327
ID Q06124
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
JAK2PTPN11Tyr327NSKPKKSyIATQGCLphosphorylation
up-regulates activity		8995399SIGNOR-236270
JAK1PTPN11Tyr327NSKPKKSyIATQGCLphosphorylation
up-regulates activity		8995399SIGNOR-236274
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
JAK2phosphorylation
up-regulates
→
PTPN11
PTyr327		phosphorylation
up-regulates
→		PTPN118995399SIGNOR-236270
JAK1phosphorylation
up-regulates
→
PTPN11
PTyr327		phosphorylation
up-regulates
→		PTPN118995399SIGNOR-236274
Regulator Mechanism/Effect Target SIGNOR-ID
JAK2phosphorylation
→
up-regulates activity 		PTPN11SIGNOR-236270
JAK1phosphorylation
→
up-regulates activity 		PTPN11SIGNOR-236274