| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK3 | BCL2L1 | Ser49 | ESEMETPsAINGNPS | phosphorylation up-regulates | 21336504 | SIGNOR-172230 |
| CDK1 | BCL2L1 | – | phosphorylation down-regulates activity | 19917720 | SIGNOR-267986 | |
| MAPK8 | BCL2L1 | Ser62 | PSWHLADsPAVNGAT | phosphorylation down-regulates | 12633850 | SIGNOR-99219 |
| JNK | BCL2L1 | Thr115 | LTSQLHItPGTAYQS | phosphorylation down-regulates | 10617621 | SIGNOR-73638 |
| JNK | BCL2L1 | Ser62 | PSWHLADsPAVNGAT | phosphorylation down-regulates | 12633850 | SIGNOR-99215 |
| JNK | BCL2L1 | Thr47 | GTESEMEtPSAINGN | phosphorylation down-regulates | 10617621 | SIGNOR-73642 |
| CDK2 | BCL2L1 | Ser73 | NGATGHSsSLDAREV | phosphorylation up-regulates activity | 27239332 | SIGNOR-278242 |
| IKBKB | BCL2L1 | – | phosphorylation down-regulates quantity | 19488402 | SIGNOR-279529 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK3 | phosphorylation up-regulates → | BCL2L1 PSer49 | phosphorylation up-regulates → | BCL2L1 | 21336504 | SIGNOR-172230 |
| MAPK8 | phosphorylation up-regulates → | BCL2L1 PSer62 | phosphorylation down-regulates ⊣ | BCL2L1 | 12633850 | SIGNOR-99219 |
| JNK | phosphorylation up-regulates → | BCL2L1 PThr115 | phosphorylation down-regulates ⊣ | BCL2L1 | 10617621 | SIGNOR-73638 |
| JNK | phosphorylation up-regulates → | BCL2L1 PSer62 | phosphorylation down-regulates ⊣ | BCL2L1 | 12633850 | SIGNOR-99215 |
| JNK | phosphorylation up-regulates → | BCL2L1 PThr47 | phosphorylation down-regulates ⊣ | BCL2L1 | 10617621 | SIGNOR-73642 |
| CDK2 | phosphorylation up-regulates → | BCL2L1 PSer73 | phosphorylation up-regulates → | BCL2L1 | 27239332 | SIGNOR-278242 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK3 | phosphorylation → up-regulates | BCL2L1 | SIGNOR-172230 |
| CDK1 | phosphorylation → down-regulates activity | BCL2L1 | SIGNOR-267986 |
| MAPK8 | phosphorylation down-regulates | BCL2L1 | SIGNOR-99219 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-73638 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-99215 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-73642 |
| CDK2 | phosphorylation → up-regulates activity | BCL2L1 | SIGNOR-278242 |
| IKBKB | phosphorylation → down-regulates quantity | BCL2L1 | SIGNOR-279529 |
