Summary

Name BCL2L1
Full Name Bcl-2-like protein 1
Synonyms Bcl2-L-1, Apoptosis regulator Bcl-X | BCL2L, BCLX
Primary ID Q07817
Links - -
Type protein
Relations 41
Pathways Acute Myeloid Leukemia, KIT in AML, COVID-19 Causal Network, FLT3-ITD in AML, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
Inhibitors 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide; N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide; Obatoclax mesylate; ABT-737; chelerythrine
Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation BCL2L1 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2L1 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png phosphorylation BCL2L1 0.769
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.752
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png binding APAF1 0.835
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates quantity by stabilization img/indirect-activation.png BCL2L1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCL2L1 0.637
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML, FLT3-ITD in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2L1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates img/direct_inhibition.png binding BCL2L1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2L1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ down-regulates activity img/indirect_inhibition.png BCL2L1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.956
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png binding BECN1 0.917
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.845
Publications: 2 Organism: Homo Sapiens,
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2L1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition BCL2L1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2L1 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding VDAC1 0.579
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2L1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.34
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates img/direct_inhibition.png binding BAX 0.739
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png binding BAK1 0.742
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma
+ down-regulates img/indirect_inhibition.png HIP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2L1 0.956
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png binding BCL2L1 0.62
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML, COVID-19 Causal Network, FLT3-ITD in AML, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L1 0.55
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.365
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.433
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.856
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png binding BAD 0.845
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
+ up-regulates quantity img/indirect-activation.png translation regulation BCL2L1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CASP9 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2L1 0.271
Publications: 1 Organism: Homo Sapiens