Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK1	MCL1	Thr92	EVPDVTAtPARLLFF	phosphorylation down-regulates quantity by destabilization	20526282	SIGNOR-165867
DYRK1A	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates quantity	32587776	SIGNOR-279703
MAPK8	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates	18676833	SIGNOR-179816
GSK3A	MCL1	Ser159 View in OncoXplorer	NNTSTDGsLPSTPPP	phosphorylation down-regulates quantity by destabilization	16543145	SIGNOR-251217
Gbeta	MCL1	–		phosphorylation up-regulates	18676833	SIGNOR-270042
DYRK1A	MCL1	Ser159 View in OncoXplorer	NNTSTDGsLPSTPPP	phosphorylation up-regulates quantity	32587776	SIGNOR-279704
CyclinB/CDK1	MCL1	Thr92	EVPDVTAtPARLLFF	phosphorylation down-regulates quantity by destabilization	18676833	SIGNOR-216900
MAPK3	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates	18676833	SIGNOR-179812
ERK1/2	MCL1	–		phosphorylation up-regulates	18676833	SIGNOR-270158
GSK3B	MCL1	Ser159 View in OncoXplorer	NNTSTDGsLPSTPPP	phosphorylation down-regulates quantity by destabilization	16543145	SIGNOR-251242
MAPK1	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates	12223490	SIGNOR-92593
MAPK1	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates	18676833	SIGNOR-179808
MAPK8	MCL1	Thr163 View in OncoXplorer	TDGSLPStPPPAEEE	phosphorylation up-regulates	12223490	SIGNOR-92597
GSK3B	MCL1	Ser159 View in OncoXplorer	NNTSTDGsLPSTPPP	phosphorylation down-regulates	16543145	SIGNOR-145200

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK1	phosphorylation up-regulates →	MCL1 PThr92	phosphorylation down-regulates ⊣	MCL1	20526282	SIGNOR-165867
DYRK1A	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	32587776	SIGNOR-279703
MAPK8	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	18676833	SIGNOR-179816
GSK3A	phosphorylation up-regulates →	MCL1 PSer159	phosphorylation down-regulates ⊣	MCL1	16543145	SIGNOR-251217
DYRK1A	phosphorylation up-regulates →	MCL1 PSer159	phosphorylation up-regulates →	MCL1	32587776	SIGNOR-279704
CyclinB/CDK1	phosphorylation up-regulates →	MCL1 PThr92	phosphorylation down-regulates ⊣	MCL1	18676833	SIGNOR-216900
MAPK3	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	18676833	SIGNOR-179812
GSK3B	phosphorylation up-regulates →	MCL1 PSer159	phosphorylation down-regulates ⊣	MCL1	16543145	SIGNOR-251242
MAPK1	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	12223490	SIGNOR-92593
MAPK1	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	18676833	SIGNOR-179808
MAPK8	phosphorylation up-regulates →	MCL1 PThr163	phosphorylation up-regulates →	MCL1	12223490	SIGNOR-92597
GSK3B	phosphorylation up-regulates →	MCL1 PSer159	phosphorylation down-regulates ⊣	MCL1	16543145	SIGNOR-145200

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK1	phosphorylation down-regulates quantity by destabilization	MCL1	SIGNOR-165867
DYRK1A	phosphorylation → up-regulates quantity	MCL1	SIGNOR-279703
MAPK8	phosphorylation → up-regulates	MCL1	SIGNOR-179816
GSK3A	phosphorylation down-regulates quantity by destabilization	MCL1	SIGNOR-251217
Gbeta	phosphorylation → up-regulates	MCL1	SIGNOR-270042
DYRK1A	phosphorylation → up-regulates quantity	MCL1	SIGNOR-279704
CyclinB/CDK1	phosphorylation down-regulates quantity by destabilization	MCL1	SIGNOR-216900
MAPK3	phosphorylation → up-regulates	MCL1	SIGNOR-179812
ERK1/2	phosphorylation → up-regulates	MCL1	SIGNOR-270158
GSK3B	phosphorylation down-regulates quantity by destabilization	MCL1	SIGNOR-251242
MAPK1	phosphorylation → up-regulates	MCL1	SIGNOR-92593
MAPK1	phosphorylation → up-regulates	MCL1	SIGNOR-179808
MAPK8	phosphorylation → up-regulates	MCL1	SIGNOR-92597
GSK3B	phosphorylation down-regulates	MCL1	SIGNOR-145200