Summary

Name MCL1
Full Name Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT | BCL2L3
Primary ID Q07820
Links - -
Type protein
Relations 18
Pathways MLL in AML
Inhibitors N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MCL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MCL1 0.22
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MCL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation MCL1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ down-regulates img/direct_inhibition.png chemical inhibition MCL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MCL1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK/BAX 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ down-regulates img/direct_inhibition.png binding BAX 0.31
Publications: 1 Organism: Homo Sapiens