| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | MCL1 | Thr92 | EVPDVTAtPARLLFF | phosphorylation down-regulates quantity by destabilization | 18676833 | SIGNOR-216900 |
| CDK1 | MCL1 | Thr92 | EVPDVTAtPARLLFF | phosphorylation down-regulates quantity by destabilization | 20526282 | SIGNOR-165867 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | MCL1 PThr92 | phosphorylation down-regulates ⊣ | MCL1 | 18676833 | SIGNOR-216900 |
| CDK1 | phosphorylation up-regulates → | MCL1 PThr92 | phosphorylation down-regulates ⊣ | MCL1 | 20526282 | SIGNOR-165867 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation![]() down-regulates quantity by destabilization | MCL1 | SIGNOR-216900 |
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | MCL1 | SIGNOR-165867 |