| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates quantity | 32587776 | SIGNOR-279703 |
| MAPK8 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 18676833 | SIGNOR-179816 |
| MAPK3 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 18676833 | SIGNOR-179812 |
| MAPK1 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 12223490 | SIGNOR-92593 |
| MAPK1 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 18676833 | SIGNOR-179808 |
| MAPK8 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 12223490 | SIGNOR-92597 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 32587776 | SIGNOR-279703 |
| MAPK8 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 18676833 | SIGNOR-179816 |
| MAPK3 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 18676833 | SIGNOR-179812 |
| MAPK1 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 12223490 | SIGNOR-92593 |
| MAPK1 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 18676833 | SIGNOR-179808 |
| MAPK8 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 12223490 | SIGNOR-92597 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → up-regulates quantity | MCL1 | SIGNOR-279703 |
| MAPK8 | phosphorylation → up-regulates | MCL1 | SIGNOR-179816 |
| MAPK3 | phosphorylation → up-regulates | MCL1 | SIGNOR-179812 |
| MAPK1 | phosphorylation → up-regulates | MCL1 | SIGNOR-92593 |
| MAPK1 | phosphorylation → up-regulates | MCL1 | SIGNOR-179808 |
| MAPK8 | phosphorylation → up-regulates | MCL1 | SIGNOR-92597 |
