| Name | PPARA |
| ID | Q07869 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 239-466 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | PPARA | Ser280 | FHCCQCTsVETVTEL | phosphorylation up-regulates activity | 30745182 | SIGNOR-278515 |
| ERK1/2 | PPARA | – | phosphorylation up-regulates activity | 10187842 | SIGNOR-270180 | |
| MAPK1 | PPARA | Ser12 | ESPLCPLsPLEAGDL | phosphorylation up-regulates activity | 10187842 | SIGNOR-249433 |
| MAPK1 | PPARA | Ser21 | LEAGDLEsPLSEEFL | phosphorylation up-regulates activity | 10187842 | SIGNOR-249434 |
| Gbeta | PPARA | – | phosphorylation up-regulates activity | 10187842 | SIGNOR-270079 | |
| MAPK3 | PPARA | Ser21 | LEAGDLEsPLSEEFL | phosphorylation up-regulates activity | 10187842 | SIGNOR-249474 |
| MAPK3 | PPARA | Ser12 | ESPLCPLsPLEAGDL | phosphorylation up-regulates activity | 10187842 | SIGNOR-249473 |
| GSK3A | PPARA | Ser280 | FHCCQCTsVETVTEL | phosphorylation up-regulates activity | 30745182 | SIGNOR-277431 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | PPARA PSer280 | phosphorylation up-regulates → | PPARA | 30745182 | SIGNOR-278515 |
| MAPK1 | phosphorylation up-regulates → | PPARA PSer12 | phosphorylation up-regulates → | PPARA | 10187842 | SIGNOR-249433 |
| MAPK1 | phosphorylation up-regulates → | PPARA PSer21 | phosphorylation up-regulates → | PPARA | 10187842 | SIGNOR-249434 |
| MAPK3 | phosphorylation up-regulates → | PPARA PSer21 | phosphorylation up-regulates → | PPARA | 10187842 | SIGNOR-249474 |
| MAPK3 | phosphorylation up-regulates → | PPARA PSer12 | phosphorylation up-regulates → | PPARA | 10187842 | SIGNOR-249473 |
| GSK3A | phosphorylation up-regulates → | PPARA PSer280 | phosphorylation up-regulates → | PPARA | 30745182 | SIGNOR-277431 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation → up-regulates activity | PPARA | SIGNOR-278515 |
| ERK1/2 | phosphorylation → up-regulates activity | PPARA | SIGNOR-270180 |
| MAPK1 | phosphorylation → up-regulates activity | PPARA | SIGNOR-249433 |
| MAPK1 | phosphorylation → up-regulates activity | PPARA | SIGNOR-249434 |
| Gbeta | phosphorylation → up-regulates activity | PPARA | SIGNOR-270079 |
| MAPK3 | phosphorylation → up-regulates activity | PPARA | SIGNOR-249474 |
| MAPK3 | phosphorylation → up-regulates activity | PPARA | SIGNOR-249473 |
| GSK3A | phosphorylation → up-regulates activity | PPARA | SIGNOR-277431 |