Summary

Name PPARA
Full Name Peroxisome proliferator-activated receptor alpha
Synonyms PPAR-alpha, Nuclear receptor subfamily 1 group C member 1 | NR1C1, PPAR
Primary ID Q07869
Links - -
Type protein
Relations 15
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ACSL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png LPL 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AQP3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLIN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC25A20 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Liver