| + |
MAPK1 | up-regulates activity 
phosphorylation
|
PPARA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249433 |
Ser12 |
ESPLCPLsPLEAGDL |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10187842 |
We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced trans-activation occurs through the phosphorylation of two mitogen-activated protein kinase sites at positions 12 and 21, both of which are conserved across evolution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249434 |
Ser21 |
LEAGDLEsPLSEEFL |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10187842 |
We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced trans-activation occurs through the phosphorylation of two mitogen-activated protein kinase sites at positions 12 and 21, both of which are conserved across evolution. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
PPARA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249473 |
Ser12 |
ESPLCPLsPLEAGDL |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10187842 |
We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced trans-activation occurs through the phosphorylation of two mitogen-activated protein kinase sites at positions 12 and 21, both of which are conserved across evolution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249474 |
Ser21 |
LEAGDLEsPLSEEFL |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10187842 |
We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced trans-activation occurs through the phosphorylation of two mitogen-activated protein kinase sites at positions 12 and 21, both of which are conserved across evolution. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression 
transcriptional regulation
|
PPARA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249534 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
ACSL1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255044 |
|
|
Homo sapiens |
Caki-1 Cell |
| pmid |
sentence |
| 17150915 |
To investigate the intimate function of PPARalpha in the kidney, we analyzed the target gene expression in human metastatic renal cell carcinoma cell line, Caki-1, using small interfering RNA (siRNA) against PPARalpha and real-time RT-PCR methods. We found that some selected genes (long-chain fatty-acid-CoA ligase (FACL1), carnitine palmitoyltransferase 1A (CPT1A), adipose differentiation-related protein (ADRP) and aquaporin 3 (AQP3)) were down-regulated by PPARalpha siRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates activity
|
LPL |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16511610 |
The effect of fibrates on the metabolism of triglyceride-rich lipoproteins is due to a PPAR-alpha-dependent stimulation of lipoprotein lipase and of apolipoprotein (apo)A-V and to an inhibition of apoC-III expression, whereas the increase in plasma HDL-cholesterol depends partly on an overexpression of apoA-I and apoA-II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
PPARA |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
PPARA |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | up-regulates
binding
|
PPARA |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11369442 |
Surprisingly, shp potentiated transcription by pparalpha/rxralpha heterodimers from the hd-ppre. This is the first demonstration of positive transcriptional activity attributable to shp. Together, these results suggest that shp can modulate pparalpha/rxralpha-mediated transcription in a response element-specific manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
AQP3 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255045 |
|
|
Homo sapiens |
Caki-1 Cell |
| pmid |
sentence |
| 17150915 |
To investigate the intimate function of PPARalpha in the kidney, we analyzed the target gene expression in human metastatic renal cell carcinoma cell line, Caki-1, using small interfering RNA (siRNA) against PPARalpha and real-time RT-PCR methods. We found that some selected genes (long-chain fatty-acid-CoA ligase (FACL1), carnitine palmitoyltransferase 1A (CPT1A), adipose differentiation-related protein (ADRP) and aquaporin 3 (AQP3)) were down-regulated by PPARalpha siRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gemfibrozil | up-regulates activity
chemical activation
|
PPARA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258318 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 21889235 |
The combination of stilbene scaffold and gemfibrozil enhances the PPARα agonistic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
CPT1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255047 |
|
|
Homo sapiens |
Caki-1 Cell |
| pmid |
sentence |
| 17150915 |
To investigate the intimate function of PPARalpha in the kidney, we analyzed the target gene expression in human metastatic renal cell carcinoma cell line, Caki-1, using small interfering RNA (siRNA) against PPARalpha and real-time RT-PCR methods. We found that some selected genes (long-chain fatty-acid-CoA ligase (FACL1), carnitine palmitoyltransferase 1A (CPT1A), adipose differentiation-related protein (ADRP) and aquaporin 3 (AQP3)) were down-regulated by PPARalpha siRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
PLIN2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255046 |
|
|
Homo sapiens |
Caki-1 Cell |
| pmid |
sentence |
| 17150915 |
To investigate the intimate function of PPARalpha in the kidney, we analyzed the target gene expression in human metastatic renal cell carcinoma cell line, Caki-1, using small interfering RNA (siRNA) against PPARalpha and real-time RT-PCR methods. We found that some selected genes (long-chain fatty-acid-CoA ligase (FACL1), carnitine palmitoyltransferase 1A (CPT1A), adipose differentiation-related protein (ADRP) and aquaporin 3 (AQP3)) were down-regulated by PPARalpha siRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
SLC25A20 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255049 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19577614 |
CACT is upregulated by PPARalpha and PPARdelta, probably by binding to a functional PPRE at position +45 to +57 relative to the transcription start site. The upregulation of CACT by PPARalpha and PPARdelta, which are both important for the regulation of fatty acid oxidation in tissues during fasting, may increase the import of acylcarnitine into the mitochondrial matrix during fasting. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
PPARA
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