Summary

Name PPARA
Full Name Peroxisome proliferator-activated receptor alpha
Synonyms PPAR-alpha, Nuclear receptor subfamily 1 group C member 1 | NR1C1, PPAR
Primary ID Q07869
Links - -
Type protein
Relations 35
Pathways Circadian clock
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.6
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.576
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.2
Publications: 2 Organism: Rattus Norvegicus, Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARA 0.594
Publications: 1 Organism: Mus Musculus
Tissue: Liver
Pathways:Circadian clock
+ up-regulates img/indirect-activation.png Fatty_acid_oxidation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Kidney
Pathways:Circadian clock
+ up-regulates img/direct-activation.png binding PPARA 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.562
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 2 Organism: Mus Musculus
Tissue: Liver
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPARA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding PPARA 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AQP3 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ACSL1 0.549
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 3 Organism: Homo Sapiens, In Vitro, Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARA 0.353
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png LPL 0.59
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.594
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARA 0.278
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARA 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1A 0.628
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC25A20 0.491
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png chemical activation PPARA 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLIN2 0.545
Publications: 1 Organism: Homo Sapiens