| Name | SOS1 |
| ID | Q07889 |
| Role | substrate |
| Enzymatic Domains |
DH 200-390 PROSITE-ProRule
PH 444-548 PROSITE-ProRule
N-terminal Ras-GEF 597-741 PROSITE-ProRule
Ras-GEF 780-1019 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | SOS1 | Ser1167 | ESAPAESsPSKIMSK | phosphorylation down-regulates activity | 8816480 | SIGNOR-244584 |
| ERK1/2 | SOS1 | – | phosphorylation down-regulates activity | 20724475 | SIGNOR-244591 | |
| MAPK3 | SOS1 | Ser1167 | ESAPAESsPSKIMSK | phosphorylation down-regulates | 8816480 | SIGNOR-43943 |
| MAPK1 | SOS1 | Ser1197 | KAYSPRYsISDRTSI | phosphorylation down-regulates activity | 8816480 | SIGNOR-235929 |
| ERK1/2 | SOS1 | Ser1197 | KAYSPRYsISDRTSI | phosphorylation down-regulates activity | 8816480 | SIGNOR-244588 |
| MAPK3 | SOS1 | Ser1132 | TLPHGPRsASVSSIS | phosphorylation down-regulates | 8816480 | SIGNOR-43939 |
| ERK1/2 | SOS1 | Ser1132 | TLPHGPRsASVSSIS | phosphorylation down-regulates activity | 8816480 | SIGNOR-244580 |
| MAPK3 | SOS1 | – | phosphorylation down-regulates | 7478566 | SIGNOR-26338 | |
| MAPK3 | SOS1 | Ser1178 | IMSKHLDsPPAIPPR | phosphorylation down-regulates | 8816480 | SIGNOR-43947 |
| MAPK3 | SOS1 | Ser1193 | QPTSKAYsPRYSISD | phosphorylation down-regulates | 8816480 | SIGNOR-43951 |
| MAPK1 | SOS1 | – | phosphorylation down-regulates activity | 10197981 | SIGNOR-236242 | |
| MAPK1 | SOS1 | Ser1193 | QPTSKAYsPRYSISD | phosphorylation down-regulates activity | 8816480 | SIGNOR-236440 |
| MAPK1 | SOS1 | Ser1167 | ESAPAESsPSKIMSK | phosphorylation down-regulates activity | 8816480 | SIGNOR-235933 |
| ERK1/2 | SOS1 | Ser1193 | QPTSKAYsPRYSISD | phosphorylation down-regulates | 20724475 | SIGNOR-244747 |
| ERK1/2 | SOS1 | Ser1178 | IMSKHLDsPPAIPPR | phosphorylation down-regulates | 20724475 | SIGNOR-244743 |
| Gbeta | SOS1 | – | phosphorylation down-regulates | 8816480 | SIGNOR-270112 | |
| MAPK1 | SOS1 | Ser1178 | IMSKHLDsPPAIPPR | phosphorylation down-regulates activity | 8816480 | SIGNOR-235925 |
| MAPK1 | SOS1 | Ser1132 | TLPHGPRsASVSSIS | phosphorylation down-regulates activity | 8816480 | SIGNOR-235742 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1167 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244584 |
| MAPK3 | phosphorylation up-regulates → | SOS1 PSer1167 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-43943 |
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1197 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-235929 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1197 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244588 |
| MAPK3 | phosphorylation up-regulates → | SOS1 PSer1132 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-43939 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1132 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244580 |
| MAPK3 | phosphorylation up-regulates → | SOS1 PSer1178 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-43947 |
| MAPK3 | phosphorylation up-regulates → | SOS1 PSer1193 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-43951 |
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1193 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-236440 |
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1167 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-235933 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1193 | phosphorylation down-regulates ⊣ | SOS1 | 20724475 | SIGNOR-244747 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1178 | phosphorylation down-regulates ⊣ | SOS1 | 20724475 | SIGNOR-244743 |
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1178 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-235925 |
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1132 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-235742 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244584 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244591 |
| MAPK3 | phosphorylation down-regulates | SOS1 | SIGNOR-43943 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-235929 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244588 |
| MAPK3 | phosphorylation down-regulates | SOS1 | SIGNOR-43939 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244580 |
| MAPK3 | phosphorylation down-regulates | SOS1 | SIGNOR-26338 |
| MAPK3 | phosphorylation down-regulates | SOS1 | SIGNOR-43947 |
| MAPK3 | phosphorylation down-regulates | SOS1 | SIGNOR-43951 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-236242 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-236440 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-235933 |
| ERK1/2 | phosphorylation down-regulates | SOS1 | SIGNOR-244747 |
| ERK1/2 | phosphorylation down-regulates | SOS1 | SIGNOR-244743 |
| Gbeta | phosphorylation down-regulates | SOS1 | SIGNOR-270112 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-235925 |
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-235742 |