Summary

Name SOS1
Full Name Son of sevenless homolog 1
Synonyms SOS-1
Primary ID Q07889
Links - -
Type protein
Relations 34
Pathways EGFR, Insulin Receptor, Glioblastoma Multiforme, Malignant Melanoma, Acute Myeloid Leukemia, Inhibition of Apoptosis, Adipogenesis, IL6 , Colorectal Carcinoma, Luminal Breast Cancer, T cell activation, Rhabdomyosarcoma, Noonan syndrome, Thyroid cancer, Integrin Signalling, KIT in AML, FLT3 in AML, BCR-ABL in AML, PI3K/AKT, ErbB receptors in cancer, RTKs in cancer
Function Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation SOS1 0.2
Publications: 6 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Lung, Breast
+ down-regulates activity img/direct_inhibition.png phosphorylation SOS1 0.43
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Lung, Breast
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation SOS1 0.34
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SOS1 0.43
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ up-regulates quantity by stabilization img/direct-activation.png binding SOS1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor HRAS 0.76
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, ErbB receptors in cancer, Insulin Receptor, Integrin Signalling, Noonan syndrome, PI3K/AKT, RTKs in cancer, T cell activation
+ down-regulates img/direct_inhibition.png binding SOS1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ up-regulates activity img/direct-activation.png relocalization SOS1 0.96
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, PI3K/AKT, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor KRAS 0.59
Publications: 4 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor NRAS 0.62
Publications: 2 Organism: Homo Sapiens
Pathways:IL6 , Inhibition of Apoptosis, Malignant Melanoma, Noonan syndrome
+ up-regulates img/direct-activation.png binding SOS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SOS1 0.55
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, IL6 , Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png binding SOS1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding SOS1 0.45
Publications: 1 Organism: Cricetulus Griseus
Pathways:EGFR, T cell activation