Entity Details

Name MAPK3_Ser1178
ID Q07889
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK3SOS1Ser1178IMSKHLDsPPAIPPRphosphorylation
down-regulates		8816480SIGNOR-43947
ERK1/2SOS1Ser1178IMSKHLDsPPAIPPRphosphorylation
down-regulates		20724475SIGNOR-244743
MAPK1SOS1Ser1178IMSKHLDsPPAIPPRphosphorylation
down-regulates activity		8816480SIGNOR-235925
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK3phosphorylation
up-regulates
→
SOS1
PSer1178		phosphorylation
down-regulates
⊣		SOS18816480SIGNOR-43947
ERK1/2phosphorylation
up-regulates
→
SOS1
PSer1178		phosphorylation
down-regulates
⊣		SOS120724475SIGNOR-244743
MAPK1phosphorylation
up-regulates
→
SOS1
PSer1178		phosphorylation
down-regulates
⊣		SOS18816480SIGNOR-235925
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates 		SOS1SIGNOR-43947
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates 		SOS1SIGNOR-244743
MAPK1phosphorylation
→
down-regulates activity 		SOS1SIGNOR-235925