| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | SOS1 | Ser1197 | KAYSPRYsISDRTSI | phosphorylation down-regulates activity | 8816480 | SIGNOR-235929 |
| ERK1/2 | SOS1 | Ser1197 | KAYSPRYsISDRTSI | phosphorylation down-regulates activity | 8816480 | SIGNOR-244588 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | SOS1 PSer1197 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-235929 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1197 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244588 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-235929 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244588 |