| Name | TNK2 |
| ID | Q07912 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 126-385 PROSITE-ProRule
SH3 388-448 PROSITE-ProRule
CRIB 454-466
UBA 958-996 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TNK2 | WWP2 | – | phosphorylation up-regulates activity | 36773333 | SIGNOR-279302 | |
| TNK2 | WASL | – | phosphorylation up-regulates activity | 31769754 | SIGNOR-280155 | |
| TNK2 | AR | Tyr269 | QLRGDCMyAPLLGVP | phosphorylation up-regulates activity | 20383201 | SIGNOR-278194 |
| TNK2 | AR | Tyr365 | AYQSRDYyNFPLALA | phosphorylation up-regulates activity | 25950519 | SIGNOR-278195 |
| TNK2 | AKT1 | Tyr176 | EKATGRYyAMKILKK | phosphorylation up-regulates activity | 20333297 | SIGNOR-252446 |
| TNK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 28739485 | SIGNOR-279312 |
| TNK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 28739485 | SIGNOR-278348 |
| TNK2 | TNK2 | Tyr284 | LPQNDDHyVMQEHRK | phosphorylation up-regulates | 14506255 | SIGNOR-118201 |
| TNK2 | TNK2 | Tyr284 | LPQNDDHyVMQEHRK | phosphorylation up-regulates activity | 16472662 | SIGNOR-251184 |
| TNK2 | KDM3A | Tyr1114 | ITPEDRKyGTTNLHL | phosphorylation down-regulates activity | 25148682 | SIGNOR-276842 |
| TNK2 | SNX9 | – | phosphorylation up-regulates | 16316319 | SIGNOR-142569 | |
| TNK2 | AKT | Tyr176 | EKATGRYyAMKILKK | phosphorylation up-regulates activity | 20333297 | SIGNOR-252457 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TNK2 | phosphorylation up-regulates → | AR PTyr269 | phosphorylation up-regulates → | AR | 20383201 | SIGNOR-278194 |
| TNK2 | phosphorylation up-regulates → | AR PTyr365 | phosphorylation up-regulates → | AR | 25950519 | SIGNOR-278195 |
| TNK2 | phosphorylation up-regulates → | AKT1 PTyr176 | phosphorylation up-regulates → | AKT1 | 20333297 | SIGNOR-252446 |
| TNK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 28739485 | SIGNOR-279312 |
| TNK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 28739485 | SIGNOR-278348 |
| TNK2 | phosphorylation up-regulates → | TNK2 PTyr284 | phosphorylation up-regulates → | TNK2 | 14506255 | SIGNOR-118201 |
| TNK2 | phosphorylation up-regulates → | TNK2 PTyr284 | phosphorylation up-regulates → | TNK2 | 16472662 | SIGNOR-251184 |
| TNK2 | phosphorylation up-regulates → | KDM3A PTyr1114 | phosphorylation down-regulates ⊣ | KDM3A | 25148682 | SIGNOR-276842 |
| TNK2 | phosphorylation up-regulates → | AKT PTyr176 | phosphorylation up-regulates → | AKT | 20333297 | SIGNOR-252457 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TNK2 | phosphorylation → up-regulates activity | WWP2 | SIGNOR-279302 |
| TNK2 | phosphorylation → up-regulates activity | WASL | SIGNOR-280155 |
| TNK2 | phosphorylation → up-regulates activity | AR | SIGNOR-278194 |
| TNK2 | phosphorylation → up-regulates activity | AR | SIGNOR-278195 |
| TNK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252446 |
| TNK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279312 |
| TNK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-278348 |
| TNK2 | phosphorylation → up-regulates | TNK2 | SIGNOR-118201 |
| TNK2 | phosphorylation → up-regulates activity | TNK2 | SIGNOR-251184 |
| TNK2 | phosphorylation → down-regulates activity | KDM3A | SIGNOR-276842 |
| TNK2 | phosphorylation → up-regulates | SNX9 | SIGNOR-142569 |
| TNK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252457 |