+ |
TNK2 | up-regulates activity
phosphorylation
|
AKT |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252457 |
Tyr176 |
EKATGRYyAMKILKK |
Mus musculus |
|
pmid |
sentence |
20333297 |
Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. Tyr176-phosphorylated AKT localizes to the plasma membrane and promotes Thr308/Ser473-phosphorylation leading to AKT activation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Tissue: |
Prostate Adenocarcinoma Cell |
+ |
TNK2 | up-regulates activity
phosphorylation
|
AKT1 |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252446 |
Tyr176 |
EKATGRYyAMKILKK |
Mus musculus |
|
pmid |
sentence |
20333297 |
Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. Tyr176-phosphorylated AKT localizes to the plasma membrane and promotes Thr308/Ser473-phosphorylation leading to AKT activation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
TNK2 | up-regulates
phosphorylation
|
TNK2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-118201 |
Tyr284 |
LPQNDDHyVMQEHRK |
Homo sapiens |
|
pmid |
sentence |
14506255 |
Purified ack1 undergoes autophosphorylation, and autophosphorylation enhances kinase activity. We identified tyr284 in the activation loop of ack1 as the primary autophosphorylation site using mass spectrometry. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TNK2 | up-regulates activity
phosphorylation
|
TNK2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251184 |
Tyr284 |
LPQNDDHyVMQEHRK |
in vitro |
|
pmid |
sentence |
16472662 |
Purified ACK1 undergoes autophosphorylation at Tyr284, and autophosphorylation increases kinase activity |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
SRC | up-regulates activity
phosphorylation
|
TNK2 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276342 |
Tyr859 |
KKVSSTHyYLLPERP |
in vitro |
|
pmid |
sentence |
36178070 |
We identified two Src phosphorylation sites within the MHR (Y859, Y860). Addition of Src-phosphorylated MHR to the Ack1 KD enhanced enzymatic activity. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276341 |
Tyr860 |
KVSSTHYyLLPERPS |
in vitro |
|
pmid |
sentence |
36178070 |
We identified two Src phosphorylation sites within the MHR (Y859, Y860). Addition of Src-phosphorylated MHR to the Ack1 KD enhanced enzymatic activity. |
|
Publications: |
2 |
Organism: |
In Vitro |
+ |
TNK2 | up-regulates
phosphorylation
|
SNX9 |
0.521 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-142569 |
|
|
Homo sapiens |
|
pmid |
sentence |
16316319 |
We have previously shown that sh3px1, phosphorylated by ack2 (activated cdc42-associated tyrosine kinase 2), regulates the degradation of egf (epidermal growth factor) receptor. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |