Summary

Name TNK2
Full Name Activated CDC42 kinase 1
Synonyms ACK-1, Tyrosine kinase non-receptor protein 2 | ACK1
Primary ID Q07912
Links - -
Type protein
Relations 5
Function Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Mus Musculus
Tissue: Prostate Adenocarcinoma Cell
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1 Organism: Mus Musculus
Tissue: Prostate Adenocarcinoma Cell
+ up-regulates img/direct-activation.png phosphorylation TNK2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TNK2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SNX9 0.85
Publications: 1 Organism: Homo Sapiens