Entity Details

Name TNK2
ID Q07912
Role substrate
Enzymatic Domains
Protein kinase 126-385
PROSITE-ProRule
SH3 388-448
PROSITE-ProRule
CRIB 454-466
UBA 958-996
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRCTNK2–phosphorylation
up-regulates activity		26677978SIGNOR-279082
PDGFRBTNK2Tyr635PLPPPPAyDDVAQDEphosphorylation
up-regulates activity		25257795SIGNOR-276854
TNK2TNK2Tyr284
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LPQNDDHyVMQEHRKphosphorylation
up-regulates activity		16472662SIGNOR-251184
TNK2TNK2Tyr284
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LPQNDDHyVMQEHRKphosphorylation
up-regulates		14506255SIGNOR-118201
SRCTNK2Tyr859KKVSSTHyYLLPERPphosphorylation
up-regulates activity		36178070SIGNOR-276342
SRCTNK2Tyr860KVSSTHYyLLPERPSphosphorylation
up-regulates activity		36178070SIGNOR-276341
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDGFRBphosphorylation
up-regulates
→
TNK2
PTyr635		phosphorylation
up-regulates
→		TNK225257795SIGNOR-276854
TNK2phosphorylation
up-regulates
→
TNK2
PTyr284		phosphorylation
up-regulates
→		TNK216472662SIGNOR-251184
TNK2phosphorylation
up-regulates
→
TNK2
PTyr284		phosphorylation
up-regulates
→		TNK214506255SIGNOR-118201
SRCphosphorylation
up-regulates
→
TNK2
PTyr859		phosphorylation
up-regulates
→		TNK236178070SIGNOR-276342
SRCphosphorylation
up-regulates
→
TNK2
PTyr860		phosphorylation
up-regulates
→		TNK236178070SIGNOR-276341
Regulator Mechanism/Effect Target SIGNOR-ID
SRCphosphorylation
→
up-regulates activity 		TNK2SIGNOR-279082
PDGFRBphosphorylation
→
up-regulates activity 		TNK2SIGNOR-276854
TNK2phosphorylation
→
up-regulates activity 		TNK2SIGNOR-251184
TNK2phosphorylation
→
up-regulates 		TNK2SIGNOR-118201
SRCphosphorylation
→
up-regulates activity 		TNK2SIGNOR-276342
SRCphosphorylation
→
up-regulates activity 		TNK2SIGNOR-276341