| Name | SRSF1 |
| ID | Q07955 |
| Role | substrate |
| Enzymatic Domains |
RRM 1 16-91 PROSITE-ProRule
RRM 2 121-195 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK3 | SRSF1 | – | phosphorylation up-regulates activity | 8617202 | SIGNOR-273859 | |
| CLK2 | SRSF1 | – | phosphorylation up-regulates activity | 8617202 | SIGNOR-273858 | |
| DYRK1A | SRSF1 | Ser238 | SRGSPRYsPRHSRSR | phosphorylation unknown | 18658135 | SIGNOR-179615 |
| CLK1 | SRSF1 | – | phosphorylation up-regulates activity | 8617202 | SIGNOR-273857 | |
| PRKACA | SRSF1 | Ser119 | YGPPSRRsENRVVVS | phosphorylation up-regulates | 22393468 | SIGNOR-196397 |
| NEK2 | SRSF1 | – | phosphorylation down-regulates activity | 24369428 | SIGNOR-279344 | |
| SRPK2 | SRSF1 | – | phosphorylation up-regulates activity | 33602301 | SIGNOR-279660 | |
| CLK4 | SRSF1 | – | phosphorylation up-regulates activity | 8617202 | SIGNOR-273860 | |
| SRPK1 | SRSF1 | – | phosphorylation up-regulates | 10196197 | SIGNOR-66465 | |
| IRAK2 | SRSF1 | – | phosphorylation down-regulates activity | 28990926 | SIGNOR-278406 | |
| CDK11B | SRSF1 | – | phosphorylation up-regulates activity | 25529026 | SIGNOR-279499 | |
| CLK1 | SRSF1 | – | phosphorylation up-regulates activity | 23707382 | SIGNOR-279608 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | SRSF1 PSer238 | phosphorylation down-regulates ⊣ | SRSF1 | 18658135 | SIGNOR-179615 |
| PRKACA | phosphorylation up-regulates → | SRSF1 PSer119 | phosphorylation up-regulates → | SRSF1 | 22393468 | SIGNOR-196397 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CLK3 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-273859 |
| CLK2 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-273858 |
| DYRK1A | phosphorylation → unknown | SRSF1 | SIGNOR-179615 |
| CLK1 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-273857 |
| PRKACA | phosphorylation → up-regulates | SRSF1 | SIGNOR-196397 |
| NEK2 | phosphorylation → down-regulates activity | SRSF1 | SIGNOR-279344 |
| SRPK2 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-279660 |
| CLK4 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-273860 |
| SRPK1 | phosphorylation → up-regulates | SRSF1 | SIGNOR-66465 |
| IRAK2 | phosphorylation → down-regulates activity | SRSF1 | SIGNOR-278406 |
| CDK11B | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-279499 |
| CLK1 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-279608 |