Summary

Name SRSF1
Full Name Serine/arginine-rich splicing factor 1
Synonyms Alternative-splicing factor 1, ASF-1, Splicing factor, arginine/serine-rich 1, pre-mRNA-splicing factor SF2, P33 subunit | ASF, SF2, SF2P33, SFRS1
Primary ID Q07955
Links - -
Type protein
Relations 9
Function Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SRSF1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRSF1 0.401
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation SRSF1 0.367
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding SRSF1 0.307
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SRSF1 0.7
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SRSF1 0.304
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SRSF1 0.797
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Alternative_Splicing_Regulation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRSF1 0.547
Publications: 1 Organism: In Vitro