| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248676 |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 14722106 | SIGNOR-84038 | |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 15276472 | SIGNOR-127248 | |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176370 | |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates activity | 23015147 | SIGNOR-253329 | |
| PPP3CA | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates | 16442073 | SIGNOR-143979 |
| PPP3CA | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-248677 |
| PPP3CA | NFATC3 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176376 | |
| PPP3CA | NFATC2 | – | dephosphorylation up-regulates | 18676376 | SIGNOR-233435 | |
| PPP3CA | NFATC2 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176373 | |
| PPP3CA | NFATC2 | Ser168 | YREPLCLsPASSGSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248678 |
| PPP3CA | NFATC2 | Ser171 | PLCLSPAsSGSSASF | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248679 |
| PPP3CA | NFATC2 | Ser172 | LCLSPASsGSSASFI | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248680 |
| PPP3CA | NFATC2 | Ser174 | LSPASSGsSASFISD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248681 |
| PPP3CA | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248682 |
| PPP3CA | NFATC2 | Ser177 | ASSGSSAsFISDTFS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248683 |
| PPP3CA | NFATC2 | Ser180 | GSSASFIsDTFSPYT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248684 |
| PPP3CA | NFATC2 | Ser213 | QNIPAHYsPRTSPIM | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248685 |
| PPP3CA | NFATC2 | Ser217 | AHYSPRTsPIMSPRT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248686 |
| PPP3CA | NFATC2 | Ser221 | PRTSPIMsPRTSLAE | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248687 |
| PPP3CA | NFATC2 | Ser268 | VALPPGAsPQRSRSP | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248688 |
| PPP3CA | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248689 |
| PPP3CA | NFATC2 | Ser276 | PQRSRSPsPQPSSHV | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248690 |
| PPP3CA | NFATC2 | Ser280 | RSPSPQPsSHVAPQD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248691 |
| PPP3CA | NFATC2 | Ser326 | PPKMWKTsPDPSPVS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248692 |
| PPP3CA | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248693 |
| PPP3CA | NFATC4 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176379 | |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248694 |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263739 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263740 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248695 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248676 |
| PPP3CA | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-143979 |
| PPP3CA | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-248677 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer168 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248678 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer171 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248679 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer172 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248680 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer174 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248681 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248682 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer177 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248683 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer180 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248684 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer213 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248685 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer217 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248686 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer221 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248687 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer268 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248688 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248689 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer276 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248690 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer280 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248691 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer326 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248692 |
| PPP3CA | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248693 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248694 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263739 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263740 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248695 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP3CA | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248676 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-84038 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-127248 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-176370 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC1 | SIGNOR-253329 |
| PPP3CA | dephosphorylation down-regulates | FLNA | SIGNOR-143979 |
| PPP3CA | dephosphorylation → unknown | DNM2 | SIGNOR-248677 |
| PPP3CA | dephosphorylation → up-regulates | NFATC3 | SIGNOR-176376 |
| PPP3CA | dephosphorylation → up-regulates | NFATC2 | SIGNOR-233435 |
| PPP3CA | dephosphorylation → up-regulates | NFATC2 | SIGNOR-176373 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248678 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248679 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248680 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248681 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248682 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248683 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248684 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248685 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248686 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248687 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248688 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248689 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248690 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248691 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248692 |
| PPP3CA | dephosphorylation → unknown | PPP1R1A | SIGNOR-248693 |
| PPP3CA | dephosphorylation → up-regulates | NFATC4 | SIGNOR-176379 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248694 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263739 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263740 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248695 |
