Summary

Name PPP3CA
Full Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Synonyms CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform | CALNA, CNA
Primary ID Q08209
Links - -
Type protein
Relations 41
Pathways IGF and Myogenesis, T cell activation
Inhibitors cyclosporin A; tacrolimus (anhydrous)
Function Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2 0.5
Publications: 15 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation FLNA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation DNM1L 0.34
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation PPP1R1A 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation DNM2 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png dephosphorylation NFATC1 0.59
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png chemical inhibition PPP3CA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PPP3CA 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation, relocalization NFATC2 0.5
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ form complex img/form-complex.png binding Calcineurin 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/indirect-activation.png PPP3CA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png chemical activation, binding PPP3CA 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP3CA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, T cell activation
+ up-regulates img/indirect-activation.png MEF2C 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC1 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png binding PPP3CA 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NFATC3 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NFATC4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PPP3CA 0.14
Publications: 1 Organism: Homo Sapiens