Summary

Name PPP3CA
Full Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Synonyms CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform | CALNA, CNA
Primary ID Q08209
Links - -
Type protein
Relations 45
Inhibitors cyclosporin A; tacrolimus (anhydrous)
Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2 0.61
Publications: 15 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation FLNA 0.263
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation DNM1L 0.281
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation PPP1R1A 0.388
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.445
Publications: 4 Organism: Homo Sapiens, In Vitro
+ img/unknown.png dephosphorylation DNM2 0.269
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png dephosphorylation NFATC1 0.814
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC1 0.814
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/indirect-activation.png PPP3CA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PPP3CA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization, dephosphorylation NFATC2 0.61
Publications: 3 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding PPP3CA 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PPP3CA 0.281
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding PPP3CA 0.75
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding PPP3CA 0.598
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PPP3CA 0.8
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png dephosphorylation NFATC4 0.559
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PPP3CA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.254
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding Calcineurin 0.953
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/indirect-activation.png MEF2C 0.482
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation NFATC3 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP3CA 0.647
Publications: 1 Organism: Homo Sapiens