| + |
PPP3CA | up-regulates activity 
dephosphorylation
|
NFATC2 |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248678 |
Ser168 |
YREPLCLsPASSGSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248679 |
Ser171 |
PLCLSPAsSGSSASF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248680 |
Ser172 |
LCLSPASsGSSASFI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248681 |
Ser174 |
LSPASSGsSASFISD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248682 |
Ser175 |
SPASSGSsASFISDT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248683 |
Ser177 |
ASSGSSAsFISDTFS |
Homo sapiens |
|
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248684 |
Ser180 |
GSSASFIsDTFSPYT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248685 |
Ser213 |
QNIPAHYsPRTSPIM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248686 |
Ser217 |
AHYSPRTsPIMSPRT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248687 |
Ser221 |
PRTSPIMsPRTSLAE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248688 |
Ser268 |
VALPPGAsPQRSRSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248689 |
Ser274 |
ASPQRSRsPSPQPSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248690 |
Ser276 |
PQRSRSPsPQPSSHV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248691 |
Ser280 |
RSPSPQPsSHVAPQD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248692 |
Ser326 |
PPKMWKTsPDPSPVS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Publications: |
15 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
PPP3CA | down-regulates 
dephosphorylation
|
FLNA |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143979 |
Ser2152 |
TRRRRAPsVANVGSH |
Homo sapiens |
|
| pmid |
sentence |
| 16442073 |
We report that a purified c-terminal recombinant region of filamin is a suitable substrate for calcineurin in vitro. Furthermore, 1 microm cyclosporin a (csa), a specific calcineurin inhibitor, reduced the dephosphorylation of the recombinant fragment in 293ft cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CA | up-regulates activity
dephosphorylation
|
DNM1L |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248676 |
Ser637 |
VPVARKLsAREQRDC |
Homo sapiens |
|
| pmid |
sentence |
| 18838687 |
When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CA |
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4.0
PPP3CA
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