| Name | EP300 |
| ID | Q09472 |
| Role | substrate |
| Enzymatic Domains |
KIX 566-645 PROSITE-ProRule
Bromo 1049-1156 PROSITE-ProRule
CBP/p300-type HAT 1287-1663 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | EP300 | Ser106 | GPGQVMAsQAQQSSP | phosphorylation up-regulates | 20471956 | SIGNOR-165567 |
| AKT1 | EP300 | – | phosphorylation up-regulates | 17964260 | SIGNOR-158624 | |
| ERK1/2 | EP300 | Ser2315 | RSPQPVPsPRPQSQP | phosphorylation up-regulates | 17623675 | SIGNOR-244634 |
| PRKAA1 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates | 21940946 | SIGNOR-176637 |
| AKT1 | EP300 | Ser1834 | MLRRRMAsMQRTGVV | phosphorylation up-regulates | 16926151 | SIGNOR-148983 |
| HIPK2 | EP300 | – | phosphorylation up-regulates activity | 20573984 | SIGNOR-278943 | |
| CDK1 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity | 24530506 | SIGNOR-278238 |
| PRKCD | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates | 12379484 | SIGNOR-94263 |
| AKT | EP300 | Ser1834 | MLRRRMAsMQRTGVV | phosphorylation up-regulates | 16926151 | SIGNOR-244236 |
| MAPK1 | EP300 | Ser2279 | PVQPNPMsPQQHMLP | phosphorylation up-regulates | 17623675 | SIGNOR-156887 |
| ROCK2 | EP300 | – | phosphorylation up-regulates activity | 16574662 | SIGNOR-279482 | |
| ERK1/2 | EP300 | Ser1038 | STSATQSsPAPGQSK | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276455 |
| AKT | EP300 | – | phosphorylation up-regulates | 17964260 | SIGNOR-244239 | |
| CDK1 | EP300 | Ser1038 | STSATQSsPAPGQSK | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276457 |
| CDK9 | EP300 | – | phosphorylation up-regulates activity | 35745840 | SIGNOR-279690 | |
| ERK1/2 | EP300 | Ser2366 | MEQGHFAsPDQNSML | phosphorylation up-regulates | 17623675 | SIGNOR-244537 |
| RPS6KA6 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates activity | 34261798 | SIGNOR-275796 |
| SIK2 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates activity | 26983400 | SIGNOR-278368 |
| MAPK1 | EP300 | Ser2366 | MEQGHFAsPDQNSML | phosphorylation up-regulates | 17623675 | SIGNOR-156895 |
| ERK1/2 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276458 |
| CDK1 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276456 |
| CDK1 | EP300 | Ser1038 | STSATQSsPAPGQSK | phosphorylation down-regulates quantity | 24530506 | SIGNOR-278239 |
| AKT2 | EP300 | Ser1834 | MLRRRMAsMQRTGVV | phosphorylation up-regulates | 16926151 | SIGNOR-148987 |
| MAPK1 | EP300 | Ser2315 | RSPQPVPsPRPQSQP | phosphorylation up-regulates | 17623675 | SIGNOR-156891 |
| ERK1/2 | EP300 | Ser2279 | PVQPNPMsPQQHMLP | phosphorylation up-regulates | 17623675 | SIGNOR-244533 |
| AKT2 | EP300 | – | phosphorylation up-regulates | 17964260 | SIGNOR-158627 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | EP300 PSer106 | phosphorylation up-regulates → | EP300 | 20471956 | SIGNOR-165567 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2315 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244634 |
| PRKAA1 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 21940946 | SIGNOR-176637 |
| AKT1 | phosphorylation up-regulates → | EP300 PSer1834 | phosphorylation up-regulates → | EP300 | 16926151 | SIGNOR-148983 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-278238 |
| PRKCD | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 12379484 | SIGNOR-94263 |
| AKT | phosphorylation up-regulates → | EP300 PSer1834 | phosphorylation up-regulates → | EP300 | 16926151 | SIGNOR-244236 |
| MAPK1 | phosphorylation up-regulates → | EP300 PSer2279 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-156887 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer1038 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276455 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer1038 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276457 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2366 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244537 |
| RPS6KA6 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 34261798 | SIGNOR-275796 |
| SIK2 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 26983400 | SIGNOR-278368 |
| MAPK1 | phosphorylation up-regulates → | EP300 PSer2366 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-156895 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276458 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276456 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer1038 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-278239 |
| AKT2 | phosphorylation up-regulates → | EP300 PSer1834 | phosphorylation up-regulates → | EP300 | 16926151 | SIGNOR-148987 |
| MAPK1 | phosphorylation up-regulates → | EP300 PSer2315 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-156891 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2279 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244533 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates | EP300 | SIGNOR-165567 |
| AKT1 | phosphorylation → up-regulates | EP300 | SIGNOR-158624 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244634 |
| PRKAA1 | phosphorylation down-regulates | EP300 | SIGNOR-176637 |
| AKT1 | phosphorylation → up-regulates | EP300 | SIGNOR-148983 |
| HIPK2 | phosphorylation → up-regulates activity | EP300 | SIGNOR-278943 |
| CDK1 | phosphorylation → down-regulates quantity | EP300 | SIGNOR-278238 |
| PRKCD | phosphorylation down-regulates | EP300 | SIGNOR-94263 |
| AKT | phosphorylation → up-regulates | EP300 | SIGNOR-244236 |
| MAPK1 | phosphorylation → up-regulates | EP300 | SIGNOR-156887 |
| ROCK2 | phosphorylation → up-regulates activity | EP300 | SIGNOR-279482 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276455 |
| AKT | phosphorylation → up-regulates | EP300 | SIGNOR-244239 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276457 |
| CDK9 | phosphorylation → up-regulates activity | EP300 | SIGNOR-279690 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244537 |
| RPS6KA6 | phosphorylation → down-regulates activity | EP300 | SIGNOR-275796 |
| SIK2 | phosphorylation → down-regulates activity | EP300 | SIGNOR-278368 |
| MAPK1 | phosphorylation → up-regulates | EP300 | SIGNOR-156895 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276458 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276456 |
| CDK1 | phosphorylation → down-regulates quantity | EP300 | SIGNOR-278239 |
| AKT2 | phosphorylation → up-regulates | EP300 | SIGNOR-148987 |
| MAPK1 | phosphorylation → up-regulates | EP300 | SIGNOR-156891 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244533 |
| AKT2 | phosphorylation → up-regulates | EP300 | SIGNOR-158627 |