Summary

Name EP300
Full Name Histone acetyltransferase p300
Synonyms p300 HAT, E1A-associated protein p300 | P300
Primary ID Q09472
Links - -
Type protein
Relations 62
Pathways IGF and Myogenesis, p53 in cancer
Function Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png deacetylation EP300 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation KPNA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation H3F3A 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation RELA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.56
Publications: 2 Organism: Homo Sapiens
Pathways:p53 in cancer
+ up-regulates img/direct-activation.png acetylation DUSP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation SMAD7 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EP300 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation EP300 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation EP300 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation EP300 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation EP300 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EP300 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EP300 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EP300 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, relocalization EP300 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation PLAG1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation PLAGL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation MAML1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FLI1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CDX2/PAX6/P300 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EP300 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:p53 in cancer
+ up-regulates img/direct-activation.png binding MN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EP300 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity img/direct-activation.png acetylation RUNX2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EP300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT16 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation RELA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBXAS1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding P300/PCAF 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CAV3 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding MEF2C 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ form complex img/form-complex.png binding SMAD2/STAT3/EP300 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RUNX2/EP300 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png acetylation MYOD1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding EP300 0.28
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CBP/p300 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EP300 0.2
Publications: 2
+ up-regulates activity img/direct-activation.png binding EP300 0.14
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALOX15 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2A 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding MEF2D 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis