| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276458 |
| CDK1 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276456 |
| CDK1 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity | 24530506 | SIGNOR-278238 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276458 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276456 |
| CDK1 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-278238 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation![]() down-regulates quantity by destabilization | EP300 | SIGNOR-276458 |
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | EP300 | SIGNOR-276456 |
| CDK1 | phosphorylation → down-regulates quantity | EP300 | SIGNOR-278238 |