| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates | 21940946 | SIGNOR-176637 |
| PRKCD | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates | 12379484 | SIGNOR-94263 |
| RPS6KA6 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates activity | 34261798 | SIGNOR-275796 |
| SIK2 | EP300 | Ser89 | SELLRSGsSPNLNMG | phosphorylation down-regulates activity | 26983400 | SIGNOR-278368 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 21940946 | SIGNOR-176637 |
| PRKCD | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 12379484 | SIGNOR-94263 |
| RPS6KA6 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 34261798 | SIGNOR-275796 |
| SIK2 | phosphorylation up-regulates → | EP300 PSer89 | phosphorylation down-regulates ⊣ | EP300 | 26983400 | SIGNOR-278368 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation down-regulates | EP300 | SIGNOR-176637 |
| PRKCD | phosphorylation down-regulates | EP300 | SIGNOR-94263 |
| RPS6KA6 | phosphorylation → down-regulates activity | EP300 | SIGNOR-275796 |
| SIK2 | phosphorylation → down-regulates activity | EP300 | SIGNOR-278368 |
