Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
Gbeta	SREBF2	–		phosphorylation up-regulates	14988395	SIGNOR-270012
ERK1/2	SREBF2	–		phosphorylation up-regulates	14988395	SIGNOR-270141
MAPK1	SREBF2	Ser455	SIDSEPGsPLLDDAK	phosphorylation up-regulates	14988395	SIGNOR-123045
MAPK1	SREBF2	Ser432	NQNVLLMsPPASDSG	phosphorylation up-regulates	14988395	SIGNOR-123041
MAPK3	SREBF2	Ser455	SIDSEPGsPLLDDAK	phosphorylation up-regulates	14988395	SIGNOR-123053
MAPK3	SREBF2	Ser432	NQNVLLMsPPASDSG	phosphorylation up-regulates	14988395	SIGNOR-123049

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK1	phosphorylation up-regulates →	SREBF2 PSer455	phosphorylation up-regulates →	SREBF2	14988395	SIGNOR-123045
MAPK1	phosphorylation up-regulates →	SREBF2 PSer432	phosphorylation up-regulates →	SREBF2	14988395	SIGNOR-123041
MAPK3	phosphorylation up-regulates →	SREBF2 PSer455	phosphorylation up-regulates →	SREBF2	14988395	SIGNOR-123053
MAPK3	phosphorylation up-regulates →	SREBF2 PSer432	phosphorylation up-regulates →	SREBF2	14988395	SIGNOR-123049

Regulator	Mechanism/Effect	Target	SIGNOR-ID
Gbeta	phosphorylation → up-regulates	SREBF2	SIGNOR-270012
ERK1/2	phosphorylation → up-regulates	SREBF2	SIGNOR-270141
MAPK1	phosphorylation → up-regulates	SREBF2	SIGNOR-123045
MAPK1	phosphorylation → up-regulates	SREBF2	SIGNOR-123041
MAPK3	phosphorylation → up-regulates	SREBF2	SIGNOR-123053
MAPK3	phosphorylation → up-regulates	SREBF2	SIGNOR-123049