| + |
MAPK1 | up-regulates 
phosphorylation
|
SREBF2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123041 |
Ser432 |
NQNVLLMsPPASDSG |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123045 |
Ser455 |
SIDSEPGsPLLDDAK |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
SREBF2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123049 |
Ser432 |
NQNVLLMsPPASDSG |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123053 |
Ser455 |
SIDSEPGsPLLDDAK |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression 
transcriptional regulation
|
LDLR |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254453 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional activation
|
SND1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259136 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 29296233 |
These findings reveal that SREBP-2 and SREBP-1 bind to specific sites in SND1 promoter and regulate SND1 transcription in opposite ways; it is induced by SREBP-2 activating conditions and repressed by SREBP-1 overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression 
transcriptional regulation
|
ABCG8 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254456 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
NPC1L1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254452 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Our results showed a positive correlation between changes in NPC1L1 and changes in both SREBP-2 and HNF-4α mRNA expression, a finding that supports the notion that these transcription factors stimulate intestinal NPC1L1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
PCSK9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254459 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255223 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 17921436 |
Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
PON1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255224 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 20728021 |
we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
PON2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255225 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19497963 |
UPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression
transcriptional regulation
|
ABCG5 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254455 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression
transcriptional regulation
|
LRP1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980003 |
In the present study we report that specific silencing of either SREBP-1 or SREBP-2 enhanced LRP1 whereas overexpression of the active SREBP isoforms decreased LRP1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253133 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 12923220 |
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells|evidence that IDH1 may regulate lipogenesis in hepatic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
SREBF2
- 
- 