| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 21798082 | SIGNOR-252352 | |
| DUSP6 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | dephosphorylation up-regulates activity | 22848439 | SIGNOR-276983 |
| MELK | FOXO1 | – | phosphorylation down-regulates quantity | 28938528 | SIGNOR-279543 | |
| PRKG2 | FOXO1 | Ser152 | LAGQPRKsSSSRRNA | phosphorylation up-regulates activity | 22393355 | SIGNOR-279563 |
| PRKG2 | FOXO1 | Ser319 | TFRPRTSsNASTISG | phosphorylation up-regulates activity | 22393355 | SIGNOR-279564 |
| MAPKAPK5 | FOXO1 | – | phosphorylation up-regulates activity | 23878308 | SIGNOR-280037 | |
| MAST4 | FOXO1 | – | phosphorylation down-regulates activity | 29066835 | SIGNOR-279079 | |
| CDK2 | FOXO1 | Ser249 | EGGKSGKsPRRRAAS | phosphorylation down-regulates | 17038621 | SIGNOR-150028 |
| SGK1 | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 19965929 | SIGNOR-255925 |
| AKT1 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-236159 |
| CDC25A | FOXO1 | – | dephosphorylation up-regulates activity | 21670150 | SIGNOR-277139 | |
| NLK | FOXO1 | Ser329 | STISGRLsPIMTEQD | phosphorylation down-regulates activity | 20061393 | SIGNOR-273907 |
| CDK1 | FOXO1 | Ser249 | EGGKSGKsPRRRAAS | phosphorylation down-regulates | 18408765 | SIGNOR-178202 |
| PAK1 | FOXO1 | – | phosphorylation down-regulates activity | 12560069 | SIGNOR-279242 | |
| DUSP6 | FOXO1 | – | dephosphorylation up-regulates | 22521266 | SIGNOR-197194 | |
| AKT1 | FOXO1 | Ser319 | TFRPRTSsNASTISG | phosphorylation down-regulates | 11237865 | SIGNOR-105459 |
| PKN1 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates | 12560069 | SIGNOR-97882 |
| STK4 | FOXO1 | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-178186 |
| AKT | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-252346 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 30519351 | SIGNOR-277740 | |
| AKT1 | FOXO1 | – | phosphorylation down-regulates activity | 18423396 | SIGNOR-236206 | |
| AKT1 | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-236163 |
| PLK1 | FOXO1 | – | phosphorylation down-regulates activity | 32704044 | SIGNOR-278269 | |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 21440011 | SIGNOR-252348 | |
| AMPK | FOXO1 | – | phosphorylation up-regulates | 18394876 | SIGNOR-216478 | |
| CSNK1G1 | FOXO1 | Ser325 | SSNASTIsGRLSPIM | phosphorylation down-regulates activity | 11980723 | SIGNOR-250821 |
| DYRK1A | FOXO1 | Ser329 | STISGRLsPIMTEQD | phosphorylation down-regulates activity | 11311120 | SIGNOR-106829 |
| AKT | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-252347 |
| CSNK1G1 | FOXO1 | Ser322 | PRTSSNAsTISGRLS | phosphorylation down-regulates activity | 11980723 | SIGNOR-250822 |
| CDK4 | FOXO1 | Ser430 | KYTYGQSsMSPLPQM | phosphorylation up-regulates activity | 23469153 | SIGNOR-278377 |
| AKT1 | FOXO1 | – | phosphorylation down-regulates quantity by destabilization | 21440011 | SIGNOR-209647 | |
| AKT1 | FOXO1 | – | phosphorylation down-regulates | 21798082 | SIGNOR-175285 | |
| STK4 | FOXO1 | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-191847 |
| CSNK1A1 | FOXO1 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183658 | |
| PRKAA1 | FOXO1 | – | phosphorylation up-regulates | 17900900 | SIGNOR-157941 | |
| DYRK1A | FOXO1 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183670 | |
| AKT2 | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-68656 |
| AKT | FOXO1 | Ser319 | TFRPRTSsNASTISG | phosphorylation down-regulates activity | 11237865 | SIGNOR-252349 |
| AKT2 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-68652 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 18423396 | SIGNOR-252350 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP6 | dephosphorylation down-regulates ⊣ | FOXO1 PSer256 | dephosphorylation down-regulates ⊣ | FOXO1 | 22848439 | SIGNOR-276983 |
| PRKG2 | phosphorylation up-regulates → | FOXO1 PSer152 | phosphorylation up-regulates → | FOXO1 | 22393355 | SIGNOR-279563 |
| PRKG2 | phosphorylation up-regulates → | FOXO1 PSer319 | phosphorylation up-regulates → | FOXO1 | 22393355 | SIGNOR-279564 |
| CDK2 | phosphorylation up-regulates → | FOXO1 PSer249 | phosphorylation down-regulates ⊣ | FOXO1 | 17038621 | SIGNOR-150028 |
| SGK1 | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 19965929 | SIGNOR-255925 |
| AKT1 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-236159 |
| NLK | phosphorylation up-regulates → | FOXO1 PSer329 | phosphorylation down-regulates ⊣ | FOXO1 | 20061393 | SIGNOR-273907 |
| CDK1 | phosphorylation up-regulates → | FOXO1 PSer249 | phosphorylation down-regulates ⊣ | FOXO1 | 18408765 | SIGNOR-178202 |
| AKT1 | phosphorylation up-regulates → | FOXO1 PSer319 | phosphorylation down-regulates ⊣ | FOXO1 | 11237865 | SIGNOR-105459 |
| PKN1 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 12560069 | SIGNOR-97882 |
| STK4 | phosphorylation up-regulates → | FOXO1 PSer212 | phosphorylation up-regulates → | FOXO1 | 18394876 | SIGNOR-178186 |
| AKT | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-252346 |
| AKT1 | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-236163 |
| CSNK1G1 | phosphorylation up-regulates → | FOXO1 PSer325 | phosphorylation down-regulates ⊣ | FOXO1 | 11980723 | SIGNOR-250821 |
| DYRK1A | phosphorylation up-regulates → | FOXO1 PSer329 | phosphorylation down-regulates ⊣ | FOXO1 | 11311120 | SIGNOR-106829 |
| AKT | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-252347 |
| CSNK1G1 | phosphorylation up-regulates → | FOXO1 PSer322 | phosphorylation down-regulates ⊣ | FOXO1 | 11980723 | SIGNOR-250822 |
| CDK4 | phosphorylation up-regulates → | FOXO1 PSer430 | phosphorylation up-regulates → | FOXO1 | 23469153 | SIGNOR-278377 |
| STK4 | phosphorylation up-regulates → | FOXO1 PSer212 | phosphorylation up-regulates → | FOXO1 | 22898666 | SIGNOR-191847 |
| AKT2 | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-68656 |
| AKT | phosphorylation up-regulates → | FOXO1 PSer319 | phosphorylation down-regulates ⊣ | FOXO1 | 11237865 | SIGNOR-252349 |
| AKT2 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-68652 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252352 |
| DUSP6 | dephosphorylation → up-regulates activity | FOXO1 | SIGNOR-276983 |
| MELK | phosphorylation → down-regulates quantity | FOXO1 | SIGNOR-279543 |
| PRKG2 | phosphorylation → up-regulates activity | FOXO1 | SIGNOR-279563 |
| PRKG2 | phosphorylation → up-regulates activity | FOXO1 | SIGNOR-279564 |
| MAPKAPK5 | phosphorylation → up-regulates activity | FOXO1 | SIGNOR-280037 |
| MAST4 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-279079 |
| CDK2 | phosphorylation down-regulates | FOXO1 | SIGNOR-150028 |
| SGK1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-255925 |
| AKT1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-236159 |
| CDC25A | dephosphorylation → up-regulates activity | FOXO1 | SIGNOR-277139 |
| NLK | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-273907 |
| CDK1 | phosphorylation down-regulates | FOXO1 | SIGNOR-178202 |
| PAK1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-279242 |
| DUSP6 | dephosphorylation → up-regulates | FOXO1 | SIGNOR-197194 |
| AKT1 | phosphorylation down-regulates | FOXO1 | SIGNOR-105459 |
| PKN1 | phosphorylation down-regulates | FOXO1 | SIGNOR-97882 |
| STK4 | phosphorylation → up-regulates | FOXO1 | SIGNOR-178186 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252346 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-277740 |
| AKT1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-236206 |
| AKT1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-236163 |
| PLK1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-278269 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252348 |
| AMPK | phosphorylation → up-regulates | FOXO1 | SIGNOR-216478 |
| CSNK1G1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-250821 |
| DYRK1A | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-106829 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252347 |
| CSNK1G1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-250822 |
| CDK4 | phosphorylation → up-regulates activity | FOXO1 | SIGNOR-278377 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO1 | SIGNOR-209647 |
| AKT1 | phosphorylation down-regulates | FOXO1 | SIGNOR-175285 |
| STK4 | phosphorylation → up-regulates | FOXO1 | SIGNOR-191847 |
| CSNK1A1 | phosphorylation down-regulates | FOXO1 | SIGNOR-183658 |
| PRKAA1 | phosphorylation → up-regulates | FOXO1 | SIGNOR-157941 |
| DYRK1A | phosphorylation down-regulates | FOXO1 | SIGNOR-183670 |
| AKT2 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-68656 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252349 |
| AKT2 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-68652 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252350 |
