Summary

Name FOXO1
Full Name Forkhead box protein O1
Synonyms Forkhead box protein O1A, Forkhead in rhabdomyosarcoma | FKHR, FOXO1A
Primary ID Q12778
Links - -
Type protein
Relations 69
Pathways Adipogenesis, FAP: In vitro induction of adipogenesis, FAP: Adipogenic transcriptional cascade, FAP: Glucocorticoids, FAP: Insulin-mediated adipogenesis, FAP: SIRT1, FAP: INSR, Inhibition of Apoptosis, Leptin Signaling, Myofiber: IGF1R, Myofiber: IL6 and atrophy, Myostatin, Pericyte: In vitro induction of adipogenesis, Rhabdomyosarcoma, Satellite: IGF1, Satellite: IGF1R, WNT/FLT3
Function Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FOXO1 0.58
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.638
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.53
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.2
Publications: 6 Organism: In Vitro, Homo Sapiens, Mus Musculus
Pathways:FAP: Insulin-mediated adipogenesis, Insulin Signaling, Inhibition of Apoptosis, Leptin Signaling, Rhabdomyosarcoma, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.645
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.866
Publications: 3 Organism: In Vitro, Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO1 0.866
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.465
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.599
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.525
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.605
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Signaling
+ up-regulates img/direct-activation.png phosphorylation FOXO1 0.352
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6PC1 0.2
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.272
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ down-regulates img/indirect_inhibition.png Adipogenesis 0.7
Publications: 4 Organism: Mus Musculus
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.387
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ up-regulates img/direct-activation.png phosphorylation FOXO1 0.433
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation POMC 0.421
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates img/direct_inhibition.png relocalization FOXO1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:FAP: Insulin-mediated adipogenesis, Insulin Signaling, Inhibition of Apoptosis, Leptin Signaling, Rhabdomyosarcoma, WNT/FLT3
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2D 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation SMURF1 0.252
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png deacetylation FOXO1 0.804
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IDH1 0.262
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARGC1A 0.568
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NPY 0.416
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.58
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Rhabdomyosarcoma
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO1 0.866
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, IGF and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FSHB 0.357
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png FOXO1 0.501
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Leptin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.525
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.566
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.421
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.33
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FOXO1 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.562
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.445
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PCK1 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GK 0.255
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png deacetylation FOXO1 0.804
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png Metabolism 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP1 0.392
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO1 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AGRP 0.458
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling