| + |
STK4 | up-regulates 
phosphorylation
|
FOXO1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178186 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191847 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
CDK2 | down-regulates 
phosphorylation
|
FOXO1 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150028 |
Ser249 |
EGGKSGKsPRRRAAS |
Homo sapiens |
|
| pmid |
sentence |
| 17038621 |
Cdk2 specifically phosphorylated foxo1 at serine-249 (ser249) in vitro and in vivo. Phosphorylation of ser249 resulted in cytoplasmic localization and inhibition of foxo1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
CDK1 | down-regulates
phosphorylation
|
FOXO1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178202 |
Ser249 |
EGGKSGKsPRRRAAS |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 18408765 |
Overexpression of cdk1 inhibits the transcriptional activity of foxo1 in pca cells through s249 phosphorylation on foxo1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates activity
phosphorylation
|
FOXO1 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68652 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
|
| pmid |
sentence |
| 10377430 |
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68656 |
Thr24 |
LPRPRSCtWPLPRPE |
Homo sapiens |
|
| pmid |
sentence |
| 10377430 |
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates activity
phosphorylation
|
FOXO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252346 |
Ser256 |
SPRRRAAsMDNNSKF |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. These results indicate that phosphorylation by PKB/Akt negatively regulates FKHR1 by promoting export from the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252349 |
Ser319 |
TFRPRTSsNASTISG |
Homo sapiens |
|
| pmid |
sentence |
| 11237865 |
The transcription factor, forkhead in rhabdomyosarcoma (fkhr), is phosphorylated at three amino acid residues (thr-24, ser-256 and ser-319) by protein kinase b (pkb)alpha.Fkhr (forkhead in rhabdomyosarcoma), afx (all1 fused gene from chromosome x) and fkhrl1 (fkhr-like 1) are phosphorylated directly by pkb in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252347 |
Thr24 |
LPRPRSCtWPLPRPE |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252350 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21440011 |
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277740 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 30519351 |
The results showed that TNC induced the cytoplasmic translocation of pFOXO1 via regulation of AKT activation. As shown in Fig. 3C, stimulation of PANC-1 cells with exogenous TNC markedly increased the phosphorylation of AKT and FOXO1. Our study showed that pFOXO1 translocates from the nucleus to the cell cytoplasm after exogenous TNC treatment, which indicates that its transcriptional activity was inhibited. |
|
| Publications: |
7 |
Organism: |
In Vitro, Homo Sapiens, Mus Musculus |
| Pathways: | FAP: Insulin-mediated adipogenesis, Insulin Signaling, Inhibition of Apoptosis, Leptin Signaling, Rhabdomyosarcoma, WNT/FLT3 |
| + |
AKT1 | down-regulates activity
phosphorylation
|
FOXO1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236159 |
Ser256 |
SPRRRAAsMDNNSKF |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236163 |
Thr24 |
LPRPRSCtWPLPRPE |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236206 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export ofFoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Publications: |
3 |
Organism: |
In Vitro, Mus Musculus |
| Pathways: | Adipogenesis, IGF and Myogenesis |
| + |
PKN1 | down-regulates
phosphorylation
|
FOXO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97882 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12560069 |
Furthermore, estrogen induced phosphorylation and perinuclear localization of the cell survival forkhead transcription factor fkhr in the cytoplasm in a pak1-dependent manner. In addition, pak1 directly interacted with fkhr and phosphorylated it. The noticed phosphorylation-dependent exclusion of fkhr from the nucleus impaired the ability of fkhr to activate its target fas ligand promoter containing the fkhr binding motif (fre) in cells treated with estrogen or expressing catalytically active pak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | up-regulates activity
dephosphorylation
|
FOXO1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276983 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
|
| pmid |
sentence |
| 22848439 |
It has been previously demonstrated that MKP-3 dephosphorylates FOXO1 on Ser256 and promotes nuclear translocation of FOXO1 , which subsequentially binds to the promoters of gluconeogenic genes and turns on the gluconeogenic program.|We also reported that MKP-3 can activate FOXO1 by at least dephosphorylating Ser 256, one of the Akt phosphorylation sites xref . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation, relocalization
|
FOXO1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105459 |
Ser319 |
TFRPRTSsNASTISG |
Homo sapiens |
|
| pmid |
sentence |
| 11237865 |
The transcription factor, forkhead in rhabdomyosarcoma (FKHR), is phosphorylated at three amino acid residues (Thr-24, Ser-256 and Ser-319) by protein kinase b (PKB)alpha. FKHR (forkhead in rhabdomyosarcoma), AFX (all1 fused gene from chromosome x) and FKHRL1 (FKHR-like 1) are phosphorylated directly by PKB in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236209 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175285 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the FoxO family, and stimulates protein synthesis via the mammalian target of rapamycin (mTOR) and glycogen synthase kinase 3b (GSK3B). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Adipogenesis, IGF and Myogenesis |
| + |
CSNK1G1 | down-regulates activity
phosphorylation
|
FOXO1 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250822 |
Ser322 |
PRTSSNAsTISGRLS |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250821 |
Ser325 |
SSNASTIsGRLSPIM |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
NLK | down-regulates activity
phosphorylation
|
FOXO1 |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273907 |
Ser329 |
STISGRLsPIMTEQD |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 20061393 |
Here, we report that the transforming growth factor-beta-activated kinase (TAK1)-Nemo-like kinase (NLK) pathway negatively regulates FOXO1. We show that NLK binds and phosphorylates FOXO1 at Pro-directed Ser/Thr residues in the transactivation domain. The phosphorylation by TAK1-NLK pathway inhibits the transcriptional activity of FOXO1 and excludes FOXO1 from the nucleus, which is independent of phosphatidylinositol 3-kinase/Akt pathway. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DYRK1A | down-regulates activity
phosphorylation
|
FOXO1 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106829 |
Ser329 |
STISGRLsPIMTEQD |
Homo sapiens |
|
| pmid |
sentence |
| 11311120 |
The kinase dyrk1a phosphorylates the transcription factor fkhr at ser329 in vitro, a novel in vivo phosphorylation siteser(329) phosphorylation also decreases the ability of fkhr to stimulate gene transactivation and reduces the proportion of fkhr present in the nucleus |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
SGK1 | down-regulates activity
phosphorylation
|
FOXO1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255925 |
Thr24 |
LPRPRSCtWPLPRPE |
Mus musculus |
|
| pmid |
sentence |
| 19965929 |
We demonstrate that SGK1 affects differentiation by direct phosphorylation of Foxo1, thereby changing its cellular localization from the nucleus to the cytosol. In addition we show that SGK1-/- cells are unable to relocalize Foxo1 to the cytosol in response to dexamethasone. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Insulin Signaling |
| + |
FOXO1 | up-regulates quantity by expression 
transcriptional regulation
|
NPY |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263502 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 28270795 |
Foxo1 (when activated) stimulates the transcription of AgRP and NPY, but suppresses the transcription of POMC; thereby antagonizing the transcriptional action of STAT3 in these hypothalamic subpopulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
FOXO1 | down-regulates quantity by repression 
transcriptional regulation
|
PPARG |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218013 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 16670091 |
FOXO1 coexpression dose-dependently repressed transcription from either the PPARgamma 1 or PPARgamma2 promoter reporter by 65%, whereas insulin (100 nm, 20-24 h) either partially or completely reversed this effect. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252069 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
The activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
FOXO1 | down-regulates
|
PPARGC1A |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | down-regulates quantity by repression
transcriptional regulation
|
GK |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181268 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription foxo1 localizes to the nucleus, where it represses hnf-4-dependent activity of the gk promoter as a corepressor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
FOXO1 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183658 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT/FLT3 |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | down-regulates quantity by repression
transcriptional regulation
|
POMC |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263503 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 28270795 |
Foxo1 (when activated) stimulates the transcription of AgRP and NPY, but suppresses the transcription of POMC; thereby antagonizing the transcriptional action of STAT3 in these hypothalamic subpopulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
FOXO1 | up-regulates quantity
transcriptional regulation
|
SMURF1 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256268 |
|
|
Mus musculus |
Skeletal Muscle |
| pmid |
sentence |
| 21798082 |
FoxO factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF1), leading to the ubiquitylation of myosin and other muscle proteins (see below), and their degradation via the proteasome |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256258 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15125842 |
The IGF-1/PI3K/Akt pathway, which has been shown to induce hypertrophy, prevents induction of requisite atrophy mediators, namely the muscle-specific ubiquitin ligases MAFbx and MuRF1. Moreover, the mechanism for this inhibition involves Akt-mediated inhibition of the FoxO family of transcription factors; |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
FOXO1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254973 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
Constitutively active Foxo1 prevents the differentiation of preadipocytes, while dominant-negative Foxo1 restores adipocyte differentiation of fibroblasts from insulin receptor-deficient mice. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254981 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
�The present data provide a direct link between insulin signaling through Irs _ PI 3-kinase _ Akt and adipogenesis through Foxo1 phosphorylation. Inhibition of Foxo1 via phosphorylation appears to be required during the clonal expansion phase, and our data show that unrestrained Foxo1 activity prevents terminal differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254977 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
�The present data provide a direct link between insulin signaling through Irs _ PI 3-kinase _ Akt and adipogenesis through Foxo1 phosphorylation. Inhibition of Foxo1 via phosphorylation appears to be required during the clonal expansion phase, and our data show that unrestrained Foxo1 activity prevents terminal differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178281 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18423396 |
Akt1/Pkb-alpha was found to be the major regulator of phosphorylation and nuclear export of Foxo1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Publications: |
4 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
TRIM63 |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235367 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18612045 |
Transcriptional reporter assays performed in both HepG2 and C2C12 cells demonstrate that the MuRF1 promoter is highly responsive to dexamethasone-activated glucocorticoid receptor (GR) and FoxO1 individually, while co-overexpression of GR and FoxO1 leads to a dramatic synergistic increase in reporter activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235712 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
BCL2L11 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12913110 |
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
SIRT1 | down-regulates quantity by destabilization
deacetylation
|
FOXO1 |
0.804 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217975 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181195 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | up-regulates
dephosphorylation
|
FOXO1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
IGFBP1 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Reporter gene studies in hepg2 hepatoma cells show that fkhr stimulates insulin-like growth factor-binding protein-1 promoter activity through an irs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267787 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
phosphorylation
|
FOXO1 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157941 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
AGRP |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28270795 |
Foxo1 (when activated) stimulates the transcription of AgRP and NPY, but suppresses the transcription of POMC; thereby antagonizing the transcriptional action of STAT3 in these hypothalamic subpopulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
FOXO1 | up-regulates
|
Metabolism |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253010 |
|
|
|
|
| pmid |
sentence |
| 18391974 |
Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body energy metabolism. |
|
| Publications: |
1 |
| + |
AKT1 | down-regulates quantity by destabilization
phosphorylation
|
FOXO1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21440011 |
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, IGF and Myogenesis |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO1 |
0.804 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
SIRT1 controls the acetylation of FOXO transcription factors, which are important regulators of lipid and glucose metabolism as well as stress response. On the other hand, SIRT1 can also stimulate the gluconeogenic transcriptional program by deacetylating and activating FOXO1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
AKT | down-regulates
relocalization
|
FOXO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252351 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FAP: Insulin-mediated adipogenesis, Insulin Signaling, Inhibition of Apoptosis, Leptin Signaling, Rhabdomyosarcoma, WNT/FLT3 |
| + |
CDC25A | up-regulates activity
dephosphorylation
|
FOXO1 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21670150 |
In this study, we revealed that Cdc25A enhances Foxo1 stability by dephosphorylating Cdk2, and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates
phosphorylation
|
FOXO1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The energy sensor AMP-activated protein kinase (AMPK) has been shown to directly phosphorylate FoxO factors at six regulatory sites that are distinct from the Akt phosphorylation sites, resulting in FoxO activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
FOXO1 | down-regulates quantity by repression
transcriptional regulation
|
FSHB |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254185 |
|
|
Mus musculus |
LbetaT2 Cell |
| pmid |
sentence |
| 24065703 |
We demonstrate that FOXO1 represses basal and GnRH-induced Fshb transcription in LβT2 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1B |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277739 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 30519351 |
To date , we have found that TNC regulates the transcriptional activity of FOXO1. And p27Kip1 is one of the transcriptional targets of FOXO1 (Fig. 5A). We speculated that TNC could regulate the binding of FOXO1 to the CDKN1B promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates activity
|
FOXO1 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Insulin disrupts irs-dependent transactivation by fkhr, and phosphorylation of ser-256 by pkb is necessary and sufficient to mediate this effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Leptin Signaling |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2D |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256146 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | down-regulates activity
binding
|
TCF4 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262529 |
|
|
Homo sapiens |
Colonic Cancer Cell Line |
| pmid |
sentence |
| 18250171 |
Here we show that the beta-catenin binding to FOXO serves a dual effect. beta-catenin, through binding, enhances FOXO transcriptional activity. In addition, FOXO competes with TCF for interaction with beta-catenin, thereby inhibiting TCF transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT/FLT3 |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2B |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates
phosphorylation
|
FOXO1 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183670 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | down-regulates activity
binding
|
STAT3 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263496 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25510553 |
FoxO1, which is up-regulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to specificity protein 1 (SP1)-pro-opiomelanocortin (POMC) promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling, Rhabdomyosarcoma |
3.0
FOXO1
- 
- 