| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-236159 |
| DUSP6 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | dephosphorylation up-regulates activity | 22848439 | SIGNOR-276983 |
| PKN1 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates | 12560069 | SIGNOR-97882 |
| AKT2 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-68652 |
| AKT | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-252346 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-236159 |
| DUSP6 | dephosphorylation down-regulates ⊣ | FOXO1 PSer256 | dephosphorylation down-regulates ⊣ | FOXO1 | 22848439 | SIGNOR-276983 |
| PKN1 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 12560069 | SIGNOR-97882 |
| AKT2 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-68652 |
| AKT | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-252346 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-236159 |
| DUSP6 | dephosphorylation → up-regulates activity | FOXO1 | SIGNOR-276983 |
| PKN1 | phosphorylation down-regulates | FOXO1 | SIGNOR-97882 |
| AKT2 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-68652 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252346 |
