| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | FOXO1 | Ser329 | STISGRLsPIMTEQD | phosphorylation down-regulates activity | 11311120 | SIGNOR-106829 |
| NLK | FOXO1 | Ser329 | STISGRLsPIMTEQD | phosphorylation down-regulates activity | 20061393 | SIGNOR-273907 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | FOXO1 PSer329 | phosphorylation down-regulates ⊣ | FOXO1 | 11311120 | SIGNOR-106829 |
| NLK | phosphorylation up-regulates → | FOXO1 PSer329 | phosphorylation down-regulates ⊣ | FOXO1 | 20061393 | SIGNOR-273907 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-106829 |
| NLK | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-273907 |