| Name | MAP3K12 |
| ID | Q12852 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 125-366 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K12 | MAP2K7 | – | phosphorylation up-regulates activity | 28111074 | SIGNOR-279630 | |
| MAP3K12 | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 11781833 | SIGNOR-113664 |
| MAP3K12 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates activity | 25594179 | SIGNOR-279629 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K12 | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 11781833 | SIGNOR-113664 |
| MAP3K12 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 25594179 | SIGNOR-279629 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K12 | phosphorylation → up-regulates activity | MAP2K7 | SIGNOR-279630 |
| MAP3K12 | phosphorylation → up-regulates | MYL12B | SIGNOR-113664 |
| MAP3K12 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-279629 |