4.0
Summary
| Name |  MAP3K12View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase 12 |
| Synonyms | Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase | ZPK |
| Primary ID | Q12852 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP3K12 | up-regulates activity 
phosphorylation
|
MAP2K4 | 0.57 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K12 | up-regulates
phosphorylation
|
MYL12B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K12 | up-regulates activity
phosphorylation
|
MAP2K7 | 0.554 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAP3K12 | 0.377 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAPK8IP1 | down-regulates 
binding
|
MAP3K12 | 0.517 |
| Publications: | 1 | Organism: | Homo Sapiens | |