| Name | PTPRJ |
| ID | Q12913 |
| Role | phosphatase |
| Enzymatic Domains |
Fibronectin type-III 1 121-209 PROSITE-ProRule
Fibronectin type-III 2 207-291 PROSITE-ProRule
Fibronectin type-III 3 271-364 PROSITE-ProRule
Fibronectin type-III 4 368-456 PROSITE-ProRule
Fibronectin type-III 5 457-541 PROSITE-ProRule
Fibronectin type-III 6 542-623 PROSITE-ProRule
Fibronectin type-III 7 625-720 PROSITE-ProRule
Fibronectin type-III 8 721-817 PROSITE-ProRule
Fibronectin type-III 9 816-902 PROSITE-ProRule
Tyrosine-protein phosphatase 1041-1298 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | LAT | – | dephosphorylation down-regulates | 11259588 | SIGNOR-105787 | |
| PTPRJ | LAT | – | dephosphorylation down-regulates activity | 11259588 | SIGNOR-248696 | |
| PTPRJ | JAK2 | Tyr813 | NSLFTPDyELLTEND | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277093 |
| PTPRJ | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277094 |
| PTPRJ | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248697 |
| PTPRJ | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248698 |
| PTPRJ | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248699 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76088 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76092 |
| PTPRJ | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76096 |
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76100 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1715686 | SIGNOR-21295 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1715686 | SIGNOR-21299 |
| PTPRJ | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1715686 | SIGNOR-21303 |
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1715686 | SIGNOR-21307 |
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 16778204 | SIGNOR-147161 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates | 16778204 | SIGNOR-147165 |
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248700 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248701 |
| PTPRJ | MET | Tyr1365 | NVKCVAPyPSLLSSE | dephosphorylation down-regulates | 12475979 | SIGNOR-96347 |
| PTPRJ | MET | Tyr1349 | STFIGEHyVHVNATY | dephosphorylation down-regulates activity | 12475979 | SIGNOR-248702 |
| PTPRJ | MET | Tyr1365 | NVKCVAPyPSLLSSE | dephosphorylation down-regulates activity | 12475979 | SIGNOR-248703 |
| PTPRJ | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 12062403 | SIGNOR-248704 |
| PTPRJ | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22898603 | SIGNOR-276978 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15735685 | SIGNOR-248705 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 26556953 | SIGNOR-276977 |
| PTPRJ | FLT1 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-101272 | |
| PTPRJ | PLCG1 | – | dephosphorylation down-regulates | 11259588 | SIGNOR-105790 | |
| PTPRJ | PLCG1 | – | dephosphorylation unknown | 11259588 | SIGNOR-248706 | |
| PTPRJ | MAPK3 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-101282 | |
| PTPRJ | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248707 |
| PTPRJ | PIK3R1 | – | dephosphorylation down-regulates | 18348712 | SIGNOR-178049 | |
| PTPRJ | MAPK1 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-101279 | |
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates | 19494114 | SIGNOR-161536 |
| PTPRJ | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248708 |
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates activity | 19494114 | SIGNOR-101276 |
| PTPRJ | CTNNB1 | – | dephosphorylation up-regulates activity | 25386896 | SIGNOR-276992 | |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates | 18936167 | SIGNOR-181672 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates | 18936167 | SIGNOR-181676 |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248709 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248710 |
| PTPRJ | FLT3 | – | dephosphorylation down-regulates activity | 21262971 | SIGNOR-277092 | |
| PTPRJ | CEACAM3 | – | dephosphorylation down-regulates activity | 35850306 | SIGNOR-277091 | |
| PTPRJ | PI3K | – | dephosphorylation down-regulates | 18348712 | SIGNOR-252727 | |
| PTPRJ | ERK1/2 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-269919 | |
| PTPRJ | Gbeta | – | dephosphorylation down-regulates | 12771128 | SIGNOR-269897 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr813 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277093 |
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr868 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277094 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248697 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248698 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248699 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76088 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76092 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76096 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76100 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21295 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21299 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21303 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21307 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147161 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147165 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248700 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248701 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1365 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-96347 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1349 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-248702 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1365 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-248703 |
| PTPRJ | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 12062403 | SIGNOR-248704 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22898603 | SIGNOR-276978 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15735685 | SIGNOR-248705 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 26556953 | SIGNOR-276977 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 19494114 | SIGNOR-248707 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-161536 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-248708 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-101276 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181672 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181676 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248709 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248710 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates | LAT | SIGNOR-105787 |
| PTPRJ | dephosphorylation → down-regulates activity | LAT | SIGNOR-248696 |
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277093 |
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277094 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248697 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248698 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248699 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76088 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76092 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76096 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76100 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21295 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21299 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21303 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21307 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147161 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147165 |
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248700 |
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248701 |
| PTPRJ | dephosphorylation down-regulates | MET | SIGNOR-96347 |
| PTPRJ | dephosphorylation → down-regulates activity | MET | SIGNOR-248702 |
| PTPRJ | dephosphorylation → down-regulates activity | MET | SIGNOR-248703 |
| PTPRJ | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248704 |
| PTPRJ | dephosphorylation → down-regulates activity | SRC | SIGNOR-276978 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-248705 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-276977 |
| PTPRJ | dephosphorylation down-regulates | FLT1 | SIGNOR-101272 |
| PTPRJ | dephosphorylation down-regulates | PLCG1 | SIGNOR-105790 |
| PTPRJ | dephosphorylation → unknown | PLCG1 | SIGNOR-248706 |
| PTPRJ | dephosphorylation down-regulates | MAPK3 | SIGNOR-101282 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248707 |
| PTPRJ | dephosphorylation down-regulates | PIK3R1 | SIGNOR-178049 |
| PTPRJ | dephosphorylation down-regulates | MAPK1 | SIGNOR-101279 |
| PTPRJ | dephosphorylation down-regulates | MAPK1 | SIGNOR-161536 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248708 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-101276 |
| PTPRJ | dephosphorylation → up-regulates activity | CTNNB1 | SIGNOR-276992 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181672 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181676 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248709 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248710 |
| PTPRJ | dephosphorylation → down-regulates activity | FLT3 | SIGNOR-277092 |
| PTPRJ | dephosphorylation → down-regulates activity | CEACAM3 | SIGNOR-277091 |
| PTPRJ | dephosphorylation down-regulates | PI3K | SIGNOR-252727 |
| PTPRJ | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269919 |
| PTPRJ | dephosphorylation down-regulates | Gbeta | SIGNOR-269897 |