Summary

Name PTPRJ
Full Name Receptor-type tyrosine-protein phosphatase eta
Synonyms Protein-tyrosine phosphatase eta, R-PTP-eta, Density-enhanced phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J | DEP1
Primary ID Q12913
Links - -
Type protein
Relations 38
Function Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation KDR 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation KDR 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation RET 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RET 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation EGFR 0.33
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.14
Publications: 8 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.39
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.37
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.37
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.28
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation LAT 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png CBL 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FLT1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PLCG1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation LAT 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PI3K 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation PLCG1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PIK3R1 0.22
Publications: 1 Organism: Homo Sapiens