Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CSNK1E	TRAF3	Tyr116	EILALQIyCRNESRG	phosphorylation up-regulates activity	32779804	SIGNOR-277525
PTPN6	TRAF3	Tyr446	SLYSQPFyTGYFGYK	dephosphorylation down-regulates activity	32779804	SIGNOR-277526
CSNK1E	TRAF3	Tyr446	SLYSQPFyTGYFGYK	phosphorylation up-regulates activity	32779804	SIGNOR-277524
PTPN6	TRAF3	Tyr116	EILALQIyCRNESRG	dephosphorylation down-regulates activity	32779804	SIGNOR-277527
CSNK1E	TRAF3	Ser349	QNWEEADsMKSSVES	phosphorylation up-regulates activity	26928339	SIGNOR-277212

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CSNK1E	phosphorylation up-regulates →	TRAF3 PTyr116	phosphorylation up-regulates →	TRAF3	32779804	SIGNOR-277525
PTPN6	dephosphorylation down-regulates ⊣	TRAF3 PTyr446	dephosphorylation up-regulates →	TRAF3	32779804	SIGNOR-277526
CSNK1E	phosphorylation up-regulates →	TRAF3 PTyr446	phosphorylation up-regulates →	TRAF3	32779804	SIGNOR-277524
PTPN6	dephosphorylation down-regulates ⊣	TRAF3 PTyr116	dephosphorylation up-regulates →	TRAF3	32779804	SIGNOR-277527
CSNK1E	phosphorylation up-regulates →	TRAF3 PSer349	phosphorylation up-regulates →	TRAF3	26928339	SIGNOR-277212

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CSNK1E	phosphorylation → up-regulates activity	TRAF3	SIGNOR-277525
PTPN6	dephosphorylation → down-regulates activity	TRAF3	SIGNOR-277526
CSNK1E	phosphorylation → up-regulates activity	TRAF3	SIGNOR-277524
PTPN6	dephosphorylation → down-regulates activity	TRAF3	SIGNOR-277527
CSNK1E	phosphorylation → up-regulates activity	TRAF3	SIGNOR-277212