Summary

Name TRAF3
Full Name TNF receptor-associated factor 3
Synonyms CAP-1, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1 | CAP1, CRAF1
Primary ID Q13114
Links - -
Type protein
Relations 12
Pathways COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Monocyte: IL10 transcriptional regulation, NF-KB Non Canonical, SARS-CoV INFLAMMATORY RESPONSE
Function Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TBK1 0.9
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates quantity by destabilization img/direct_inhibition.png binding MAP3K14 0.652
Publications: 1 Organism: Mus Musculus
Pathways:Innate Immune Response, NF-KB Non Canonical
+ down-regulates quantity by destabilization img/indirect_inhibition.png TRAF3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/direct-activation.png binding TRAF3 0.916
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ down-regulates activity img/direct_inhibition.png deubiquitination TRAF3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates activity img/direct_inhibition.png binding TRAF3 0.446
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding TRAF3 0.482
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.34
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png binding TRAF3 0.749
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png ubiquitination TRAF3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRAF3 0.721
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates activity img/direct_inhibition.png deubiquitination TRAF3 0.768
Publications: 1 Organism: Homo Sapiens