| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | TRAF3 | Tyr446 | SLYSQPFyTGYFGYK | dephosphorylation down-regulates activity | 32779804 | SIGNOR-277526 |
| CSNK1E | TRAF3 | Tyr446 | SLYSQPFyTGYFGYK | phosphorylation up-regulates activity | 32779804 | SIGNOR-277524 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | TRAF3 PTyr446 | dephosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277526 |
| CSNK1E | phosphorylation up-regulates → | TRAF3 PTyr446 | phosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277524 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | TRAF3 | SIGNOR-277526 |
| CSNK1E | phosphorylation → up-regulates activity | TRAF3 | SIGNOR-277524 |