| Name | PRKAA1 |
| ID | Q13131 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 27-279 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates activity | 16054095 | SIGNOR-139297 |
| AKT1 | PRKAA1 | – | phosphorylation down-regulates activity | 16340011 | SIGNOR-252739 | |
| AMPK | PRKAA1 | Ser486 | DDEITEAKsGTATPQRS | phosphorylation down-regulates activity | 17023420 | SIGNOR-256113 |
| BRSK2 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 21918180 | SIGNOR-176594 |
| CAMK2B | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 15980064 | SIGNOR-138360 |
| PRKCA | PRKAA1 | Ser496 | ATPQRSGsVSNYRSC | phosphorylation down-regulates activity | 27784766 | SIGNOR-276459 |
| PRKCB | PRKAA1 | Ser496 | ATPQRSGsVSNYRSC | phosphorylation down-regulates activity | 27784766 | SIGNOR-276460 |
| ULK1 | PRKAA1 | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-173047 | |
| CAMKK1 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 21918180 | SIGNOR-176598 |
| PRKACA | PRKAA1 | Ser491 | SSTPQRSCsAAGLHRPR | phosphorylation down-regulates activity | 17023420 | SIGNOR-256112 |
| PRKACA | PRKAA1 | Ser496 | ATPQRSGsVSNYRSC | phosphorylation down-regulates activity | 27784766 | SIGNOR-259865 |
| AKT1 | PRKAA1 | Ser496 | ATPQRSGsVSNYRSC | phosphorylation down-regulates activity | 27784766 | SIGNOR-276461 |
| CAMKK2 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 21918180 | SIGNOR-176602 |
| PIM2 | PRKAA1 | Ser467 | LQLYQVDsRTYLLDF | phosphorylation down-regulates activity | 31358902 | SIGNOR-277471 |
| AKT | PRKAA1 | – | phosphorylation down-regulates activity | 16340011 | SIGNOR-252740 | |
| PRKACA | PRKAA1 | Ser486 | DDEITEAKsGTATPQRS | phosphorylation down-regulates activity | 17023420 | SIGNOR-256110 |
| STK11 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates activity | 14976552 | SIGNOR-122721 |
| PRKAA1 | PRKAA1 | Ser486 | DDEITEAKsGTATPQRS | phosphorylation down-regulates activity | 17023420 | SIGNOR-256114 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 16054095 | SIGNOR-139297 |
| AMPK | phosphorylation up-regulates → | PRKAA1 PSer486 | phosphorylation down-regulates ⊣ | PRKAA1 | 17023420 | SIGNOR-256113 |
| BRSK2 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 21918180 | SIGNOR-176594 |
| CAMK2B | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 15980064 | SIGNOR-138360 |
| PRKCA | phosphorylation up-regulates → | PRKAA1 PSer496 | phosphorylation down-regulates ⊣ | PRKAA1 | 27784766 | SIGNOR-276459 |
| PRKCB | phosphorylation up-regulates → | PRKAA1 PSer496 | phosphorylation down-regulates ⊣ | PRKAA1 | 27784766 | SIGNOR-276460 |
| CAMKK1 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 21918180 | SIGNOR-176598 |
| PRKACA | phosphorylation up-regulates → | PRKAA1 PSer491 | phosphorylation down-regulates ⊣ | PRKAA1 | 17023420 | SIGNOR-256112 |
| PRKACA | phosphorylation up-regulates → | PRKAA1 PSer496 | phosphorylation down-regulates ⊣ | PRKAA1 | 27784766 | SIGNOR-259865 |
| AKT1 | phosphorylation up-regulates → | PRKAA1 PSer496 | phosphorylation down-regulates ⊣ | PRKAA1 | 27784766 | SIGNOR-276461 |
| CAMKK2 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 21918180 | SIGNOR-176602 |
| PIM2 | phosphorylation up-regulates → | PRKAA1 PSer467 | phosphorylation down-regulates ⊣ | PRKAA1 | 31358902 | SIGNOR-277471 |
| PRKACA | phosphorylation up-regulates → | PRKAA1 PSer486 | phosphorylation down-regulates ⊣ | PRKAA1 | 17023420 | SIGNOR-256110 |
| STK11 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 14976552 | SIGNOR-122721 |
| PRKAA1 | phosphorylation up-regulates → | PRKAA1 PSer486 | phosphorylation down-regulates ⊣ | PRKAA1 | 17023420 | SIGNOR-256114 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK11 | phosphorylation → up-regulates activity | PRKAA1 | SIGNOR-139297 |
| AKT1 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-252739 |
| AMPK | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-256113 |
| BRSK2 | phosphorylation → up-regulates | PRKAA1 | SIGNOR-176594 |
| CAMK2B | phosphorylation → up-regulates | PRKAA1 | SIGNOR-138360 |
| PRKCA | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-276459 |
| PRKCB | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-276460 |
| ULK1 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-173047 |
| CAMKK1 | phosphorylation → up-regulates | PRKAA1 | SIGNOR-176598 |
| PRKACA | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-256112 |
| PRKACA | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-259865 |
| AKT1 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-276461 |
| CAMKK2 | phosphorylation → up-regulates | PRKAA1 | SIGNOR-176602 |
| PIM2 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-277471 |
| AKT | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-252740 |
| PRKACA | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-256110 |
| STK11 | phosphorylation → up-regulates activity | PRKAA1 | SIGNOR-122721 |
| PRKAA1 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-256114 |