Summary

Name PRKAA1
Full Name 5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, 2.7.11.27, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, 2.7.11.31, Tau-protein kinase PRKAA1, 2.7.11.26 | AMPK1
Primary ID Q13131
Links - -
Type protein
Relations 101
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation KPNA2 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAB1 0.98
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAI1 0.19
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.80
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TP53 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MFF
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.53
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TBC1D1 0.46
Publications: 1 Organism: Homo Sapiens
Tissue: Myotube
+ down-regulates img/direct_inhibition.png phosphorylation GFPT1 0.62
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC5 0.42
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GFPT1 0.62
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNF4A 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR2C2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation POU2F1 0.41
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.64
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.42
Publications: 8 Organism: Homo Sapiens, Caenorhabditis Elegans,
Tissue: Liver
+ up-regulates activity img/direct-activation.png phosphorylation FOXO
Publications: 7 Organism: Homo Sapiens, Caenorhabditis Elegans
+ up-regulates img/direct-activation.png phosphorylation PFKFB3 0.59
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ down-regulates img/direct_inhibition.png phosphorylation ZNF692 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PPARGC1A 0.42
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle, Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation KLC2 0.50
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RRN3 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRY1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RPTOR 0.62
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.21
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation LIPE 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EP300 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SYN1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TET2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GBF1 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKAA1 0.68
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.65
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MLXIPL 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC1 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown PRKAA1
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown NR0B2 0.21
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYCS 0.10
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation FOXO
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.24
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png unknown PRKAA1
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UCP3 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.38
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation SREBF1 0.50
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AMPK
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Brain, Heart, Liver
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation G6PC 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PCK1 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCD 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1C 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown TGFB1 0.07
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation FOXO1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SIRT1 0.56
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png phosphorylation ULK1 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation NAMPT 0.38
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown NRF1 0.26
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/indirect_inhibition.png unknown NOS2 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A4 0.30
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle