Summary

Name PRKAA1
Full Name 5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, 2.7.11.27, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, 2.7.11.31, Tau-protein kinase PRKAA1, 2.7.11.26 | AMPK1
Primary ID Q13131
Links - -
Type protein
Relations 110
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation GLI1
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAPDH
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation DDIT3
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation PIAS1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CFTR
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KPNA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAB1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAI1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.31
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MFF 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TBC1D1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Myotube
+ down-regulates img/direct_inhibition.png phosphorylation GFPT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC5 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GFPT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNF4A 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR2C2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.22
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation POU2F1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.28
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.44
Publications: 8 Organism: Homo Sapiens, , Caenorhabditis Elegans
Tissue: Liver
+ up-regulates activity img/direct-activation.png phosphorylation FOXO 0.2
Publications: 7 Organism: Homo Sapiens, Caenorhabditis Elegans
+ up-regulates img/direct-activation.png phosphorylation PFKFB3 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ down-regulates img/direct_inhibition.png phosphorylation ZNF692 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PPARGC1A 0.22
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle, Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation KLC2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RRN3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRY1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RPTOR 0.51
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation LIPE 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EP300 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SYN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TET2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation GBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKAA1 0.42
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png NOS2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/indirect-activation.png SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1C 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/indirect_inhibition.png TGFB1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYCS 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation FOXO1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ULK1 0.6
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AMPK 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Brain, Heart, Liver
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ down-regulates activity img/indirect_inhibition.png PRKAA1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation G6PC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PCK1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SREBF1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MLXIPL 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation NAMPT 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png PRKAA1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png NR0B2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A4 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UCP3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png NRF1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.14
Publications: 1 Organism: Homo Sapiens