| Name | PAK1 |
| ID | Q13153 |
| Role | substrate |
| Enzymatic Domains |
CRIB 75-88 PROSITE-ProRule
Protein kinase 270-521 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248493 |
| CDK5 | PAK1 | Thr212 | VIEPLPVtPTRDVAT | phosphorylation down-regulates activity | 11604394 | SIGNOR-249328 |
| PPM1E | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248761 |
| MAPK3 | PAK1 | Thr292 | YTAMDVAtGQEVAIK | phosphorylation down-regulates | 14993270 | SIGNOR-123074 |
| Gbeta | PAK1 | – | phosphorylation down-regulates | 14993270 | SIGNOR-270086 | |
| MAP3K11 | PAK1 | Ser204 | TKSVYTRsVIEPLPV | phosphorylation up-regulates activity | 30664689 | SIGNOR-279417 |
| MAP3K11 | PAK1 | Ser133 | DVLEFYNsKKTSNSQ | phosphorylation up-regulates activity | 30664689 | SIGNOR-279418 |
| ERK1/2 | PAK1 | – | phosphorylation down-regulates | 14993270 | SIGNOR-270186 | |
| PPP2CB | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248599 |
| PPP2CA | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248641 |
| EPHA3 | PAK1 | Tyr153 | TDKSAEDyNSSNALN | phosphorylation up-regulates activity | 26944939 | SIGNOR-278398 |
| PPM1E | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248760 |
| PPM1A | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248491 |
| CDK19 | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation unknown | 19520772 | SIGNOR-185000 |
| PAK1 | PAK1 | Ser199 | PRPEHTKsVYTRSVI | phosphorylation up-regulates activity | 9032240 | SIGNOR-250216 |
| PPM1F | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248531 |
| OXSR1 | PAK1 | Thr84 | LPSDFEHtIHVGFDA | phosphorylation down-regulates activity | 14707132 | SIGNOR-250210 |
| PPP2CA | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248643 |
| CyclinD3/CDK11B | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273129 |
| STK11 | PAK1 | Thr109 | QWARLLQtSNITKSE | phosphorylation down-regulates | 20400510 | SIGNOR-164814 |
| PDPK1 | PAK1 | Thr423 | PEQSKRStMVGTPYW | phosphorylation up-regulates activity | 10995762 | SIGNOR-250267 |
| PPM1A | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248492 |
| CDK11A | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273026 |
| PAK1 | PAK1 | Ser57 | KKDRFYRsILPGDKT | phosphorylation up-regulates activity | 9032240 | SIGNOR-250219 |
| PPP2CB | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248600 |
| PPP2CB | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248598 |
| MAPK1 | PAK1 | Thr212 | VIEPLPVtPTRDVAT | phosphorylation down-regulates activity | 15542607 | SIGNOR-249432 |
| CyclinD3/CDK11A | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273124 |
| PPP2CA | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248642 |
| PPM1F | PAK1 | – | dephosphorylation down-regulates | 20016286 | SIGNOR-162146 | |
| PPM1F | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248530 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248493 |
| CDK5 | phosphorylation up-regulates → | PAK1 PThr212 | phosphorylation down-regulates ⊣ | PAK1 | 11604394 | SIGNOR-249328 |
| PPM1E | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248761 |
| MAPK3 | phosphorylation up-regulates → | PAK1 PThr292 | phosphorylation down-regulates ⊣ | PAK1 | 14993270 | SIGNOR-123074 |
| MAP3K11 | phosphorylation up-regulates → | PAK1 PSer204 | phosphorylation up-regulates → | PAK1 | 30664689 | SIGNOR-279417 |
| MAP3K11 | phosphorylation up-regulates → | PAK1 PSer133 | phosphorylation up-regulates → | PAK1 | 30664689 | SIGNOR-279418 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248599 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248641 |
| EPHA3 | phosphorylation up-regulates → | PAK1 PTyr153 | phosphorylation up-regulates → | PAK1 | 26944939 | SIGNOR-278398 |
| PPM1E | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248760 |
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248491 |
| CDK19 | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation down-regulates ⊣ | PAK1 | 19520772 | SIGNOR-185000 |
| PAK1 | phosphorylation up-regulates → | PAK1 PSer199 | phosphorylation up-regulates → | PAK1 | 9032240 | SIGNOR-250216 |
| PPM1F | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248531 |
| OXSR1 | phosphorylation up-regulates → | PAK1 PThr84 | phosphorylation down-regulates ⊣ | PAK1 | 14707132 | SIGNOR-250210 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248643 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273129 |
| STK11 | phosphorylation up-regulates → | PAK1 PThr109 | phosphorylation down-regulates ⊣ | PAK1 | 20400510 | SIGNOR-164814 |
| PDPK1 | phosphorylation up-regulates → | PAK1 PThr423 | phosphorylation up-regulates → | PAK1 | 10995762 | SIGNOR-250267 |
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248492 |
| CDK11A | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273026 |
| PAK1 | phosphorylation up-regulates → | PAK1 PSer57 | phosphorylation up-regulates → | PAK1 | 9032240 | SIGNOR-250219 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248600 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248598 |
| MAPK1 | phosphorylation up-regulates → | PAK1 PThr212 | phosphorylation down-regulates ⊣ | PAK1 | 15542607 | SIGNOR-249432 |
| CyclinD3/CDK11A | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273124 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248642 |
| PPM1F | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248530 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248493 |
| CDK5 | phosphorylation → down-regulates activity | PAK1 | SIGNOR-249328 |
| PPM1E | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248761 |
| MAPK3 | phosphorylation down-regulates | PAK1 | SIGNOR-123074 |
| Gbeta | phosphorylation down-regulates | PAK1 | SIGNOR-270086 |
| MAP3K11 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-279417 |
| MAP3K11 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-279418 |
| ERK1/2 | phosphorylation down-regulates | PAK1 | SIGNOR-270186 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248599 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248641 |
| EPHA3 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-278398 |
| PPM1E | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248760 |
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248491 |
| CDK19 | phosphorylation → unknown | PAK1 | SIGNOR-185000 |
| PAK1 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-250216 |
| PPM1F | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248531 |
| OXSR1 | phosphorylation → down-regulates activity | PAK1 | SIGNOR-250210 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248643 |
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273129 |
| STK11 | phosphorylation down-regulates | PAK1 | SIGNOR-164814 |
| PDPK1 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-250267 |
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248492 |
| CDK11A | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273026 |
| PAK1 | phosphorylation → up-regulates activity | PAK1 | SIGNOR-250219 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248600 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248598 |
| MAPK1 | phosphorylation → down-regulates activity | PAK1 | SIGNOR-249432 |
| CyclinD3/CDK11A | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273124 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248642 |
| PPM1F | dephosphorylation down-regulates | PAK1 | SIGNOR-162146 |
| PPM1F | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248530 |