Summary

Name PAK1
Full Name Serine/threonine-protein kinase PAK 1
Synonyms Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK
Primary ID Q13153
Links - -
Type protein
Relations 82
Pathways EGFR, Toll like receptors, T cell activation
Function Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGAM1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TBCB 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTBP1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.23
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GNAZ 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ img/unknown.png phosphorylation PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.48
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:EGFR, T cell activation, Toll like receptors
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.14
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.14
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.14
Publications: 3 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation ELF3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAI1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ILK 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PXN 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITGB3BP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARAF 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.46
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HACE1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.37
Publications: 4 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VIM 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.14
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.2
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation SYN1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DYNLL1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARPC1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.28
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation PA2G4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.44
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR, T cell activation
+ up-regulates img/direct-activation.png phosphorylation PGM1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LIMK1 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK1 0.59
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation PAK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PAK1 0.59
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:EGFR, T cell activation
+ up-regulates activity img/direct-activation.png binding PAK1 0.57
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png phosphorylation BCL6 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WEE1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, T cell activation, Toll like receptors
+ down-regulates activity img/direct_inhibition.png binding PAK1 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, T cell activation, Toll like receptors
+ up-regulates img/direct-activation.png binding PAK1 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png binding PAK1 0.42
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MYLK 0.14
Publications: 1 Organism: Homo Sapiens