| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11A | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273124 |
| CDK11A | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273026 |
| CDK19 | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation unknown | 19520772 | SIGNOR-185000 |
| CyclinD3/CDK11B | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273129 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11A | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273124 |
| CDK11A | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273026 |
| CDK19 | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation down-regulates ⊣ | PAK1 | 19520772 | SIGNOR-185000 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273129 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD3/CDK11A | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273124 |
| CDK11A | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273026 |
| CDK19 | phosphorylation → unknown | PAK1 | SIGNOR-185000 |
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273129 |